The formation of mutated IgM memory B cells in rat splenic marginal zones is an antigen dependent process

Previous studies in rodents have indicated that only a minor fraction of the immunoglobulin heavy chain variable region (IGHV-Cμ) transcripts carry somatic mutations and are considered memory B cells. This is in marked contrast to humans where nearly all marginal zone B (MZ-B) cells are mutated. Her...

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Detalles Bibliográficos
Autores principales: Hendricks, Jacobus, Visser, Annie, Dammers, Peter M., Burgerhof, Johannes G. M., Bos, Nicolaas A., Kroese, Frans G. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6730915/
https://www.ncbi.nlm.nih.gov/pubmed/31490967
http://dx.doi.org/10.1371/journal.pone.0220933

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