Increased vulnerability of nigral dopamine neurons after expansion of their axonal arborization size through D2 dopamine receptor conditional knockout

Parkinson’s disease (PD) is a neurodegenerative disorder characterized by the loss of dopamine (DA) neurons in the substantia nigra pars compacta (SNc). Rare genetic mutations in genes such as Parkin, Pink1, DJ-1, α-synuclein, LRRK2 and GBA are found to be responsible for the disease in about 15% of...

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Detalles Bibliográficos
Autores principales: Giguère, Nicolas, Delignat-Lavaud, Benoît, Herborg, Freja, Voisin, Aurore, Li, Yuan, Jacquemet, Vincent, Anand-Srivastava, Madhu, Gether, Ulrik, Giros, Bruno, Trudeau, Louis-Éric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6730950/
https://www.ncbi.nlm.nih.gov/pubmed/31449520
http://dx.doi.org/10.1371/journal.pgen.1008352

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