New power of self-assembling carbonic anhydrase inhibitor: Short peptide–constructed nanofibers inspire hypoxic cancer therapy

Carbonic anhydrase (CA) IX overexpresses exclusively on cell membranes of hypoxic tumors, regulating the acidic tumor microenvironment. Small molecules of CA inhibitor modified with short peptide successfully achieve CA IX–targeted self-assembly that localizes CA inhibitors on hypoxic cancer cell su...

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Detalles Bibliográficos
Autores principales: Li, Jiayang, Shi, Kejian, Sabet, Zeinab Farhadi, Fu, Wenjiao, Zhou, Huige, Xu, Shaoxin, Liu, Tao, You, Min, Cao, Mingjing, Xu, Mengzhen, Cui, Xuejing, Hu, Bin, Liu, Ying, Chen, Chunying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6731069/
https://www.ncbi.nlm.nih.gov/pubmed/31523712
http://dx.doi.org/10.1126/sciadv.aax0937

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