Cargando…

Targeted drug combination therapy design based on driver genes

Targeted therapies against cancer types with more than one driver gene hold bright but elusive promise, since approved drugs are not available for all driver mutations and monotherapies often result in resistance. Targeting multiple driver genes in different pathways at the same time may provide an...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zsákai, Lilian, Sipos, Anna, Dobos, Judit, Erős, Dániel, Szántai-Kis, Csaba, Bánhegyi, Péter, Pató, János, Őrfi, László, Matula, Zsolt, Mikala, Gábor, Kéri, György, Peták, István, Vályi-Nagy, István
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2019
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6731102/ https://www.ncbi.nlm.nih.gov/pubmed/31523388 http://dx.doi.org/10.18632/oncotarget.26985

Ejemplares similares

The Effect of Belantamab Mafodotin on Primary Myeloma–Stroma Co-Cultures: Asymmetrical Mitochondrial Transfer between Myeloma Cells and Autologous Bone Marrow Stromal Cells
por: Matula, Zsolt, et al.
Publicado: (2023)

Molecular subtype specific efficacy of MEK inhibitors in pancreatic cancers
por: Brauswetter, Diána, et al.
Publicado: (2017)

Stromal Cells Serve Drug Resistance for Multiple Myeloma via Mitochondrial Transfer: A Study on Primary Myeloma and Stromal Cells
por: Matula, Zsolt, et al.
Publicado: (2021)

Liquid biopsy-based monitoring of residual disease in multiple myeloma by analysis of the rearranged immunoglobulin genes–A feasibility study
por: Marx, Anita, et al.
Publicado: (2023)

Nucleophosmin1 and isocitrate dehydrogenase 1 and 2 as measurable residual disease markers in acute myeloid leukemia
por: Kövy, Petra, et al.
Publicado: (2021)

Development of a 3D Tissue Culture–Based High-Content Screening Platform That Uses Phenotypic Profiling to Discriminate Selective Inhibitors of Receptor Tyrosine Kinases
por: Booij, Tijmen H., et al.
Publicado: (2016)

Characterization of new, efficient Mycobacterium tuberculosis topoisomerase-I inhibitors and their interaction with human ABC multidrug transporters
por: Temesszentandrási-Ambrus, Csilla, et al.
Publicado: (2018)

Antibody and T Cell Responses against SARS-CoV-2 Elicited by the Third Dose of BBIBP-CorV (Sinopharm) and BNT162b2 (Pfizer-BioNTech) Vaccines Using a Homologous or Heterologous Booster Vaccination Strategy
por: Matula, Zsolt, et al.
Publicado: (2022)

Comparison of antibody and T cell responses elicited by BBIBP-CorV (Sinopharm) and BNT162b2 (Pfizer-BioNTech) vaccines against SARS-CoV-2 in healthy adult humans
por: Vályi-Nagy, István, et al.
Publicado: (2021)

Novel Crizotinib–GnRH Conjugates Revealed the Significance of Lysosomal Trapping in GnRH-Based Drug Delivery Systems
por: Murányi, József, et al.
Publicado: (2019)

Targeted Venetoclax Therapy in t(11;14) Multiple Myeloma: Real World Data From Seven Hungarian Centers
por: Szita, Virág Réka, et al.
Publicado: (2022)

Isocyanide Substitution in Acridine Orange Shifts DNA Damage-Mediated Phototoxicity to Permeabilization of the Lysosomal Membrane in Cancer Cells
por: Bankó, Csaba, et al.
Publicado: (2021)

Efficacy of Incremental Next-Generation ALK Inhibitor Treatment in Oncogene-Addicted, ALK-Positive, TP53-Mutant NSCLC
por: Urbán, László, et al.
Publicado: (2020)

Decreased functional activity of multidrug resistance protein in primary colorectal cancer
por: Micsik, Tamás, et al.
Publicado: (2015)

Specific Antibody and the T-Cell Response Elicited by BNT162b2 Boosting After Two ChAdOx1 nCoV-19 in Common Variable Immunodeficiency
por: Goda, Vera, et al.
Publicado: (2022)

In Vivo Imaging of Experimental Melanoma Tumors using the Novel Radiotracer (68)Ga-NODAGA-Procainamide (PCA)
por: Kertész, István, et al.
Publicado: (2017)

Personalized First-Line Treatment of Metastatic Pancreatic Neuroendocrine Carcinoma Facilitated by Liquid Biopsy and Computational Decision Support
por: Szkukalek, Judita, et al.
Publicado: (2021)

In Vivo Imaging of Hypoxia and Neoangiogenesis in Experimental Syngeneic Hepatocellular Carcinoma Tumor Model Using Positron Emission Tomography
por: Kis, Adrienn, et al.
Publicado: (2020)

Gene Expression Changes in Femoral Head Necrosis of Human Bone Tissue
por: Balla, Bernadett, et al.
Publicado: (2011)

Stereoselective Synthesis and Antiproliferative Activities of Tetrafunctional Diterpene Steviol Derivatives
por: Bai, Dorottya, et al.
Publicado: (2023)

Invasive fungal infections among critically ill adult COVID-19 patients: First experiences from the national centre in Hungary
por: Szabo, Balint Gergely, et al.
Publicado: (2021)

Targeting Vascular Endothelial Growth Factor Receptor 2 and Protein Kinase D1 Related Pathways by a Multiple Kinase Inhibitor in Angiogenesis and Inflammation Related Processes In Vitro
por: Varga, Attila, et al.
Publicado: (2015)

Correction: Targeting Vascular Endothelial Growth Factor Receptor 2 and Protein Kinase D1 Related Pathways by a Multiple Kinase Inhibitor in Angiogenesis and Inflammation Related Processes In Vitro
por: Varga, Attila, et al.
Publicado: (2015)

MDR-1 and MRP-1 activity in peripheral blood leukocytes of rheumatoid arthritis patients
por: Micsik, Tamás, et al.
Publicado: (2015)

Inbreeding depression for kit survival at birth in a rabbit population under long-term selection
por: Curik, Ino, et al.
Publicado: (2020)

The Potential Impact of Connexin 43 Expression on Bcl-2 Protein Level and Taxane Sensitivity in Head and Neck Cancers–In Vitro Studies
por: Gurbi, Bianka, et al.
Publicado: (2019)

Use of convalescent plasma therapy in hospitalised adult patients with non-critical COVID-19: a focus on the elderly from Hungary
por: Kiss-Dala, Noemi, et al.
Publicado: (2022)

Hepatic fibrosis and factors associated with liver stiffness in HIV mono-infected individuals
por: Sulyok, Mihály, et al.
Publicado: (2017)

Needle aspiration for treating iatrogenic pneumothorax after cardiac electronic device implantation: a pilot study
por: Domokos, Dominika, et al.
Publicado: (2019)

Adaptive Immunity to Viruses: What Did We Learn from SARS-CoV-2 Infection?
por: Vályi-Nagy, István, et al.
Publicado: (2022)

Enhanced Expression of Human Epididymis Protein 4 (HE4) Reflecting Pro-Inflammatory Status Is Regulated by CFTR in Cystic Fibrosis Bronchial Epithelial Cells
por: Bene, Zsolt, et al.
Publicado: (2021)

Lost in the City: Revisiting Milgram's Experiment in the Age of Social Networks
por: Szüle, János, et al.
Publicado: (2014)

Secondary Iliac-Enteric Fistula to the Sigmoid Colon Complicated with Entero-Grafto-Cutaneous Fistula
por: Bognár, Gábor, et al.
Publicado: (2008)

Formulation Optimization of Sustained-Release Ammonio Methacrylate Copolymer Microspheres. Effects of Log P and Concentration of Polar Cosolvents, and Role of the Drug/Copolymer Ratio
por: Sipos, Péter, et al.
Publicado: (2011)

Effectiveness of IGlarLixi, a Fixed-Ratio Combination of Insulin Glargine 100 U/mL and Lixisenatide, in People with Type 2 Diabetes
por: Kis, János Tibor, et al.
Publicado: (2021)

Identification of Protein Kinase Inhibitors with a Selective Negative Effect on the Viability of Epstein-Barr Virus Infected B Cell Lines
por: Mavromatidis, Vassilis, et al.
Publicado: (2014)

Endothelial cell activation is attenuated by everolimus via transcriptional and post-transcriptional regulatory mechanisms after drug-eluting coronary stenting
por: Fejes, Zsolt, et al.
Publicado: (2018)

Outcomes of high-risk adult outpatients treated with early remdesivir therapy during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) omicron era: experiences from the national centre of Hungary
por: Gáspár, Zsófia, et al.
Publicado: (2023)

Decreased circulating dipeptidyl peptidase-4 enzyme activity is prognostic for severe outcomes in COVID-19 inpatients
por: Nádasdi, Ákos, et al.
Publicado: (2022)

t2prhd: a tool to study the patterns of repeat evolution
por: Sipos, Botond, et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_k7lbutgqpubgo9s9nuiedj0fp4