Enhanced Potency of GalNAc-Conjugated Antisense Oligonucleotides in Hepatocellular Cancer Models

Antisense oligonucleotides (ASOs) are a novel therapeutic approach to target difficult-to-drug protein classes by targeting their corresponding mRNAs. Significantly enhanced ASO activity has been achieved by the targeted delivery of ASOs to selected tissues. One example is the targeted delivery of A...

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Detalles Bibliográficos
Autores principales: Kim, Youngsoo, Jo, Minji, Schmidt, Joanna, Luo, Xiaolin, Prakash, Thazha P., Zhou, Tianyuan, Klein, Stephanie, Xiao, Xiaokun, Post, Noah, Yin, Zhengfeng, MacLeod, A. Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2019
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6731179/
https://www.ncbi.nlm.nih.gov/pubmed/31303442
http://dx.doi.org/10.1016/j.ymthe.2019.06.009

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