Ciliary exclusion of Polycystin-2 promotes kidney cystogenesis in an autosomal dominant polycystic kidney disease model

The human PKD2 locus encodes Polycystin-2 (PC2), a TRPP channel that localises to several distinct cellular compartments, including the cilium. PKD2 mutations cause Autosomal Dominant Polycystic Kidney Disease (ADPKD) and affect many cellular pathways. Data underlining the importance of ciliary PC2...

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Detalles Bibliográficos
Autores principales: Walker, Rebecca V., Keynton, Jennifer L., Grimes, Daniel T., Sreekumar, Vrinda, Williams, Debbie J., Esapa, Chris, Wu, Dongsheng, Knight, Martin M., Norris, Dominic P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6731238/
https://www.ncbi.nlm.nih.gov/pubmed/31492868
http://dx.doi.org/10.1038/s41467-019-12067-y

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