ARID1A promotes genomic stability through protecting telomere cohesion

ARID1A inactivation causes mitotic defects. Paradoxically, cancers with high ARID1A mutation rates typically lack copy number alterations (CNAs). Here, we show that ARID1A inactivation causes defects in telomere cohesion, which selectively eliminates gross chromosome aberrations during mitosis. ARID...

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Detalles Bibliográficos
Autores principales: Zhao, Bo, Lin, Jianhuang, Rong, Lijie, Wu, Shuai, Deng, Zhong, Fatkhutdinov, Nail, Zundell, Joseph, Fukumoto, Takeshi, Liu, Qin, Kossenkov, Andrew, Jean, Stephanie, Cadungog, Mark G., Borowsky, Mark E., Drapkin, Ronny, Lieberman, Paul M., Abate-Shen, Cory T., Zhang, Rugang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6731242/
https://www.ncbi.nlm.nih.gov/pubmed/31492885
http://dx.doi.org/10.1038/s41467-019-12037-4

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