Similarities and differences in patterns of germline mutation between mice and humans

Whole genome sequencing (WGS) studies have estimated the human germline mutation rate per basepair per generation (~1.2 × 10(−8)) to be higher than in mice (3.5–5.4 × 10(−9)). In humans, most germline mutations are paternal in origin and numbers of mutations per offspring increase with paternal and...

Descripción completa

Detalles Bibliográficos
Autores principales: Lindsay, Sarah J., Rahbari, Raheleh, Kaplanis, Joanna, Keane, Thomas, Hurles, Matthew E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6731245/
https://www.ncbi.nlm.nih.gov/pubmed/31492841
http://dx.doi.org/10.1038/s41467-019-12023-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6731245/
https://www.ncbi.nlm.nih.gov/pubmed/31492841
http://dx.doi.org/10.1038/s41467-019-12023-w

Ejemplares similares