Tropane alkaloids biosynthesis involves an unusual type III polyketide synthase and non-enzymatic condensation

The skeleton of tropane alkaloids is derived from ornithine-derived N-methylpyrrolinium and two malonyl-CoA units. The enzymatic mechanism that connects N-methylpyrrolinium and malonyl-CoA units remains unknown. Here, we report the characterization of three pyrrolidine ketide synthases (PYKS), AaPYK...

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Detalles Bibliográficos
Autores principales: Huang, Jian-Ping, Fang, Chengli, Ma, Xiaoyan, Wang, Li, Yang, Jing, Luo, Jianying, Yan, Yijun, Zhang, Yu, Huang, Sheng-Xiong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6731253/
https://www.ncbi.nlm.nih.gov/pubmed/31492848
http://dx.doi.org/10.1038/s41467-019-11987-z

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