Spatially clustered loci with multiple enhancers are frequent targets of HIV-1 integration

HIV-1 recurrently targets active genes and integrates in the proximity of the nuclear pore compartment in CD4(+) T cells. However, the genomic features of these genes and the relevance of their transcriptional activity for HIV-1 integration have so far remained unclear. Here we show that recurrently...

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Detalles Bibliográficos
Autores principales: Lucic, Bojana, Chen, Heng-Chang, Kuzman, Maja, Zorita, Eduard, Wegner, Julia, Minneker, Vera, Wang, Wei, Fronza, Raffaele, Laufs, Stefanie, Schmidt, Manfred, Stadhouders, Ralph, Roukos, Vassilis, Vlahovicek, Kristian, Filion, Guillaume J., Lusic, Marina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6731298/
https://www.ncbi.nlm.nih.gov/pubmed/31492853
http://dx.doi.org/10.1038/s41467-019-12046-3

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