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Pre-existing yellow fever immunity impairs and modulates the antibody response to tick-borne encephalitis vaccination
Flaviviruses have an increasing global impact as arthropod-transmitted human pathogens, exemplified by Zika, dengue, yellow fever (YF), West Nile, Japanese encephalitis, and tick-borne encephalitis (TBE) viruses. Since all flaviviruses are antigenically related, they are prone to phenomena of immuno...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6731309/ https://www.ncbi.nlm.nih.gov/pubmed/31508246 http://dx.doi.org/10.1038/s41541-019-0133-5 |
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author | Bradt, Victoria Malafa, Stefan von Braun, Amrei Jarmer, Johanna Tsouchnikas, Georgios Medits, Iris Wanke, Kerstin Karrer, Urs Stiasny, Karin Heinz, Franz X. |
author_facet | Bradt, Victoria Malafa, Stefan von Braun, Amrei Jarmer, Johanna Tsouchnikas, Georgios Medits, Iris Wanke, Kerstin Karrer, Urs Stiasny, Karin Heinz, Franz X. |
author_sort | Bradt, Victoria |
collection | PubMed |
description | Flaviviruses have an increasing global impact as arthropod-transmitted human pathogens, exemplified by Zika, dengue, yellow fever (YF), West Nile, Japanese encephalitis, and tick-borne encephalitis (TBE) viruses. Since all flaviviruses are antigenically related, they are prone to phenomena of immunological memory (‘original antigenic sin’), which can modulate immune responses in the course of sequential infections and/or vaccinations. In our study, we analyzed the influence of pre-existing YF vaccine-derived immunity on the antibody response to TBE vaccination. By comparing samples from YF pre-vaccinated and flavivirus–naive individuals, we show that YF immunity not only caused a significant impairment of the neutralizing antibody response to TBE vaccination but also a reduction of the specific TBE virus neutralizing activities (NT/ELISA-titer ratios). Our results point to a possible negative effect of pre-existing cross-reactive immunity on the outcome of flavivirus vaccination that may also pertain to other combinations of sequential flavivirus infections and/or vaccinations. |
format | Online Article Text |
id | pubmed-6731309 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-67313092019-09-10 Pre-existing yellow fever immunity impairs and modulates the antibody response to tick-borne encephalitis vaccination Bradt, Victoria Malafa, Stefan von Braun, Amrei Jarmer, Johanna Tsouchnikas, Georgios Medits, Iris Wanke, Kerstin Karrer, Urs Stiasny, Karin Heinz, Franz X. NPJ Vaccines Article Flaviviruses have an increasing global impact as arthropod-transmitted human pathogens, exemplified by Zika, dengue, yellow fever (YF), West Nile, Japanese encephalitis, and tick-borne encephalitis (TBE) viruses. Since all flaviviruses are antigenically related, they are prone to phenomena of immunological memory (‘original antigenic sin’), which can modulate immune responses in the course of sequential infections and/or vaccinations. In our study, we analyzed the influence of pre-existing YF vaccine-derived immunity on the antibody response to TBE vaccination. By comparing samples from YF pre-vaccinated and flavivirus–naive individuals, we show that YF immunity not only caused a significant impairment of the neutralizing antibody response to TBE vaccination but also a reduction of the specific TBE virus neutralizing activities (NT/ELISA-titer ratios). Our results point to a possible negative effect of pre-existing cross-reactive immunity on the outcome of flavivirus vaccination that may also pertain to other combinations of sequential flavivirus infections and/or vaccinations. Nature Publishing Group UK 2019-09-06 /pmc/articles/PMC6731309/ /pubmed/31508246 http://dx.doi.org/10.1038/s41541-019-0133-5 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Bradt, Victoria Malafa, Stefan von Braun, Amrei Jarmer, Johanna Tsouchnikas, Georgios Medits, Iris Wanke, Kerstin Karrer, Urs Stiasny, Karin Heinz, Franz X. Pre-existing yellow fever immunity impairs and modulates the antibody response to tick-borne encephalitis vaccination |
title | Pre-existing yellow fever immunity impairs and modulates the antibody response to tick-borne encephalitis vaccination |
title_full | Pre-existing yellow fever immunity impairs and modulates the antibody response to tick-borne encephalitis vaccination |
title_fullStr | Pre-existing yellow fever immunity impairs and modulates the antibody response to tick-borne encephalitis vaccination |
title_full_unstemmed | Pre-existing yellow fever immunity impairs and modulates the antibody response to tick-borne encephalitis vaccination |
title_short | Pre-existing yellow fever immunity impairs and modulates the antibody response to tick-borne encephalitis vaccination |
title_sort | pre-existing yellow fever immunity impairs and modulates the antibody response to tick-borne encephalitis vaccination |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6731309/ https://www.ncbi.nlm.nih.gov/pubmed/31508246 http://dx.doi.org/10.1038/s41541-019-0133-5 |
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