Cargando…

Pre-existing yellow fever immunity impairs and modulates the antibody response to tick-borne encephalitis vaccination

Flaviviruses have an increasing global impact as arthropod-transmitted human pathogens, exemplified by Zika, dengue, yellow fever (YF), West Nile, Japanese encephalitis, and tick-borne encephalitis (TBE) viruses. Since all flaviviruses are antigenically related, they are prone to phenomena of immuno...

Descripción completa

Detalles Bibliográficos
Autores principales: Bradt, Victoria, Malafa, Stefan, von Braun, Amrei, Jarmer, Johanna, Tsouchnikas, Georgios, Medits, Iris, Wanke, Kerstin, Karrer, Urs, Stiasny, Karin, Heinz, Franz X.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6731309/
https://www.ncbi.nlm.nih.gov/pubmed/31508246
http://dx.doi.org/10.1038/s41541-019-0133-5
_version_ 1783449664890077184
author Bradt, Victoria
Malafa, Stefan
von Braun, Amrei
Jarmer, Johanna
Tsouchnikas, Georgios
Medits, Iris
Wanke, Kerstin
Karrer, Urs
Stiasny, Karin
Heinz, Franz X.
author_facet Bradt, Victoria
Malafa, Stefan
von Braun, Amrei
Jarmer, Johanna
Tsouchnikas, Georgios
Medits, Iris
Wanke, Kerstin
Karrer, Urs
Stiasny, Karin
Heinz, Franz X.
author_sort Bradt, Victoria
collection PubMed
description Flaviviruses have an increasing global impact as arthropod-transmitted human pathogens, exemplified by Zika, dengue, yellow fever (YF), West Nile, Japanese encephalitis, and tick-borne encephalitis (TBE) viruses. Since all flaviviruses are antigenically related, they are prone to phenomena of immunological memory (‘original antigenic sin’), which can modulate immune responses in the course of sequential infections and/or vaccinations. In our study, we analyzed the influence of pre-existing YF vaccine-derived immunity on the antibody response to TBE vaccination. By comparing samples from YF pre-vaccinated and flavivirus–naive individuals, we show that YF immunity not only caused a significant impairment of the neutralizing antibody response to TBE vaccination but also a reduction of the specific TBE virus neutralizing activities (NT/ELISA-titer ratios). Our results point to a possible negative effect of pre-existing cross-reactive immunity on the outcome of flavivirus vaccination that may also pertain to other combinations of sequential flavivirus infections and/or vaccinations.
format Online
Article
Text
id pubmed-6731309
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-67313092019-09-10 Pre-existing yellow fever immunity impairs and modulates the antibody response to tick-borne encephalitis vaccination Bradt, Victoria Malafa, Stefan von Braun, Amrei Jarmer, Johanna Tsouchnikas, Georgios Medits, Iris Wanke, Kerstin Karrer, Urs Stiasny, Karin Heinz, Franz X. NPJ Vaccines Article Flaviviruses have an increasing global impact as arthropod-transmitted human pathogens, exemplified by Zika, dengue, yellow fever (YF), West Nile, Japanese encephalitis, and tick-borne encephalitis (TBE) viruses. Since all flaviviruses are antigenically related, they are prone to phenomena of immunological memory (‘original antigenic sin’), which can modulate immune responses in the course of sequential infections and/or vaccinations. In our study, we analyzed the influence of pre-existing YF vaccine-derived immunity on the antibody response to TBE vaccination. By comparing samples from YF pre-vaccinated and flavivirus–naive individuals, we show that YF immunity not only caused a significant impairment of the neutralizing antibody response to TBE vaccination but also a reduction of the specific TBE virus neutralizing activities (NT/ELISA-titer ratios). Our results point to a possible negative effect of pre-existing cross-reactive immunity on the outcome of flavivirus vaccination that may also pertain to other combinations of sequential flavivirus infections and/or vaccinations. Nature Publishing Group UK 2019-09-06 /pmc/articles/PMC6731309/ /pubmed/31508246 http://dx.doi.org/10.1038/s41541-019-0133-5 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Bradt, Victoria
Malafa, Stefan
von Braun, Amrei
Jarmer, Johanna
Tsouchnikas, Georgios
Medits, Iris
Wanke, Kerstin
Karrer, Urs
Stiasny, Karin
Heinz, Franz X.
Pre-existing yellow fever immunity impairs and modulates the antibody response to tick-borne encephalitis vaccination
title Pre-existing yellow fever immunity impairs and modulates the antibody response to tick-borne encephalitis vaccination
title_full Pre-existing yellow fever immunity impairs and modulates the antibody response to tick-borne encephalitis vaccination
title_fullStr Pre-existing yellow fever immunity impairs and modulates the antibody response to tick-borne encephalitis vaccination
title_full_unstemmed Pre-existing yellow fever immunity impairs and modulates the antibody response to tick-borne encephalitis vaccination
title_short Pre-existing yellow fever immunity impairs and modulates the antibody response to tick-borne encephalitis vaccination
title_sort pre-existing yellow fever immunity impairs and modulates the antibody response to tick-borne encephalitis vaccination
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6731309/
https://www.ncbi.nlm.nih.gov/pubmed/31508246
http://dx.doi.org/10.1038/s41541-019-0133-5
work_keys_str_mv AT bradtvictoria preexistingyellowfeverimmunityimpairsandmodulatestheantibodyresponsetotickborneencephalitisvaccination
AT malafastefan preexistingyellowfeverimmunityimpairsandmodulatestheantibodyresponsetotickborneencephalitisvaccination
AT vonbraunamrei preexistingyellowfeverimmunityimpairsandmodulatestheantibodyresponsetotickborneencephalitisvaccination
AT jarmerjohanna preexistingyellowfeverimmunityimpairsandmodulatestheantibodyresponsetotickborneencephalitisvaccination
AT tsouchnikasgeorgios preexistingyellowfeverimmunityimpairsandmodulatestheantibodyresponsetotickborneencephalitisvaccination
AT meditsiris preexistingyellowfeverimmunityimpairsandmodulatestheantibodyresponsetotickborneencephalitisvaccination
AT wankekerstin preexistingyellowfeverimmunityimpairsandmodulatestheantibodyresponsetotickborneencephalitisvaccination
AT karrerurs preexistingyellowfeverimmunityimpairsandmodulatestheantibodyresponsetotickborneencephalitisvaccination
AT stiasnykarin preexistingyellowfeverimmunityimpairsandmodulatestheantibodyresponsetotickborneencephalitisvaccination
AT heinzfranzx preexistingyellowfeverimmunityimpairsandmodulatestheantibodyresponsetotickborneencephalitisvaccination