The anti-parasitic agent suramin and several of its analogues are inhibitors of the DNA binding protein Mcm10

Minichromosome maintenance protein 10 (Mcm10) is essential for DNA unwinding by the replisome during S phase. It is emerging as a promising anti-cancer target as MCM10 expression correlates with tumour progression and poor clinical outcomes. Here we used a competition-based fluorescence polarization...

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Detalles Bibliográficos
Autores principales: Paulson, Carolyn N., John, Kristen, Baxley, Ryan M., Kurniawan, Fredy, Orellana, Kayo, Francis, Rawle, Sobeck, Alexandra, Eichman, Brandt F., Chazin, Walter J., Aihara, Hideki, Georg, Gunda I., Hawkinson, Jon E., Bielinsky, Anja-Katrin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6731595/
https://www.ncbi.nlm.nih.gov/pubmed/31409229
http://dx.doi.org/10.1098/rsob.190117

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