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Cohort profile: role of lipoproteins in cardiovascular disease—the LipidCardio study
PURPOSE: The LipidCardio Study was established for in-depth analyses of cardiovascular risk factors, providing well-defined cardiovascular and metabolic phenotypes. In particular, the role of lipoproteins in the pathobiological process and treatment of cardiovascular disease (CVD) will be a main foc...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6731918/ https://www.ncbi.nlm.nih.gov/pubmed/31481563 http://dx.doi.org/10.1136/bmjopen-2019-030097 |
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author | König, Maximilian Joshi, Samita Leistner, David M Landmesser, Ulf Sinning, David Steinhagen-Thiessen, Elisabeth Demuth, Ilja |
author_facet | König, Maximilian Joshi, Samita Leistner, David M Landmesser, Ulf Sinning, David Steinhagen-Thiessen, Elisabeth Demuth, Ilja |
author_sort | König, Maximilian |
collection | PubMed |
description | PURPOSE: The LipidCardio Study was established for in-depth analyses of cardiovascular risk factors, providing well-defined cardiovascular and metabolic phenotypes. In particular, the role of lipoproteins in the pathobiological process and treatment of cardiovascular disease (CVD) will be a main focus. PARTICIPANTS: 1005 individuals aged 21 years and older undergoing cardiac catheterisation during 17 months at a tertiary academic cardiology centre were enrolled (troponin-positive acute coronary syndrome was exclusion criterion). The baseline data not only contain detailed phenotyping, broad biochemical parameters, genetic data, but also standardised personal and family history, a screening test for cognitive impairment, pulse wave analysis and measurements of hand grip strength, among others. Blood samples were stored in a biobank for future analyses. FINDINGS TO DATE: The mean age of the participants at enrolment was 70.9±11.1 years (70% male). Coronary angiography provided evidence of obstructive coronary artery disease (CAD) in 69.9% of participants. Those with evidence of CAD were significantly more likely to be male, inactive, diabetic and with a family history of CVD than participants without CAD. About 20% of patients had lipoprotein(a) (Lp(a)) concentrations above 106.9 nmol/L (fifth quintile). These patients had significantly increased odds of obstructive CAD compared with participants in quintiles 1–4 (crude OR 1.70, 95% CI 1.17 to 2.48, p=0.005). There was reasonable evidence that with increasing severity of CAD the odds of having elevated Lp(a) increased. We were able to replicate the established strong association between specified single nucleotide polymorphisms (SNPs) in the LPA gene (rs10455872, rs3798220 and rs186696265) and the APOE gene (rs7412), and the concentration of Lp(a), validating our phenotype database and biobank. FUTURE PLANS: Mortality information will be obtained in 2 year intervals. Follow-up phone interviews will be conducted at 3 and 6 years after enrolment. We seek to cooperate with other researchers, for example, by sharing data and biobank samples. |
format | Online Article Text |
id | pubmed-6731918 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-67319182019-09-20 Cohort profile: role of lipoproteins in cardiovascular disease—the LipidCardio study König, Maximilian Joshi, Samita Leistner, David M Landmesser, Ulf Sinning, David Steinhagen-Thiessen, Elisabeth Demuth, Ilja BMJ Open Cardiovascular Medicine PURPOSE: The LipidCardio Study was established for in-depth analyses of cardiovascular risk factors, providing well-defined cardiovascular and metabolic phenotypes. In particular, the role of lipoproteins in the pathobiological process and treatment of cardiovascular disease (CVD) will be a main focus. PARTICIPANTS: 1005 individuals aged 21 years and older undergoing cardiac catheterisation during 17 months at a tertiary academic cardiology centre were enrolled (troponin-positive acute coronary syndrome was exclusion criterion). The baseline data not only contain detailed phenotyping, broad biochemical parameters, genetic data, but also standardised personal and family history, a screening test for cognitive impairment, pulse wave analysis and measurements of hand grip strength, among others. Blood samples were stored in a biobank for future analyses. FINDINGS TO DATE: The mean age of the participants at enrolment was 70.9±11.1 years (70% male). Coronary angiography provided evidence of obstructive coronary artery disease (CAD) in 69.9% of participants. Those with evidence of CAD were significantly more likely to be male, inactive, diabetic and with a family history of CVD than participants without CAD. About 20% of patients had lipoprotein(a) (Lp(a)) concentrations above 106.9 nmol/L (fifth quintile). These patients had significantly increased odds of obstructive CAD compared with participants in quintiles 1–4 (crude OR 1.70, 95% CI 1.17 to 2.48, p=0.005). There was reasonable evidence that with increasing severity of CAD the odds of having elevated Lp(a) increased. We were able to replicate the established strong association between specified single nucleotide polymorphisms (SNPs) in the LPA gene (rs10455872, rs3798220 and rs186696265) and the APOE gene (rs7412), and the concentration of Lp(a), validating our phenotype database and biobank. FUTURE PLANS: Mortality information will be obtained in 2 year intervals. Follow-up phone interviews will be conducted at 3 and 6 years after enrolment. We seek to cooperate with other researchers, for example, by sharing data and biobank samples. BMJ Publishing Group 2019-09-03 /pmc/articles/PMC6731918/ /pubmed/31481563 http://dx.doi.org/10.1136/bmjopen-2019-030097 Text en © Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/. |
spellingShingle | Cardiovascular Medicine König, Maximilian Joshi, Samita Leistner, David M Landmesser, Ulf Sinning, David Steinhagen-Thiessen, Elisabeth Demuth, Ilja Cohort profile: role of lipoproteins in cardiovascular disease—the LipidCardio study |
title | Cohort profile: role of lipoproteins in cardiovascular disease—the LipidCardio study |
title_full | Cohort profile: role of lipoproteins in cardiovascular disease—the LipidCardio study |
title_fullStr | Cohort profile: role of lipoproteins in cardiovascular disease—the LipidCardio study |
title_full_unstemmed | Cohort profile: role of lipoproteins in cardiovascular disease—the LipidCardio study |
title_short | Cohort profile: role of lipoproteins in cardiovascular disease—the LipidCardio study |
title_sort | cohort profile: role of lipoproteins in cardiovascular disease—the lipidcardio study |
topic | Cardiovascular Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6731918/ https://www.ncbi.nlm.nih.gov/pubmed/31481563 http://dx.doi.org/10.1136/bmjopen-2019-030097 |
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