Cargando…

Contralateral fatigue during severe-intensity single-leg exercise: influence of acute acetaminophen ingestion

Exhaustive single-leg exercise has been suggested to reduce time to task failure (T(lim)) during subsequent exercise in the contralateral leg by exacerbating central fatigue development. We investigated the influence of acetaminophen (ACT), an analgesic that may blunt central fatigue development, on...

Descripción completa

Detalles Bibliográficos
Autores principales: Morgan, Paul T., Bailey, Stephen J., Banks, Rhys A., Fulford, Jonathan, Vanhatalo, Anni, Jones, Andrew M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Physiological Society 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6732432/
https://www.ncbi.nlm.nih.gov/pubmed/31141387
http://dx.doi.org/10.1152/ajpregu.00084.2019
_version_ 1783449818930085888
author Morgan, Paul T.
Bailey, Stephen J.
Banks, Rhys A.
Fulford, Jonathan
Vanhatalo, Anni
Jones, Andrew M.
author_facet Morgan, Paul T.
Bailey, Stephen J.
Banks, Rhys A.
Fulford, Jonathan
Vanhatalo, Anni
Jones, Andrew M.
author_sort Morgan, Paul T.
collection PubMed
description Exhaustive single-leg exercise has been suggested to reduce time to task failure (T(lim)) during subsequent exercise in the contralateral leg by exacerbating central fatigue development. We investigated the influence of acetaminophen (ACT), an analgesic that may blunt central fatigue development, on T(lim) during single-leg exercise completed with and without prior fatiguing exercise of the contralateral leg. Fourteen recreationally active men performed single-leg severe-intensity knee-extensor exercise to T(lim) on the left (Leg(1)) and right (Leg(2)) legs without prior contralateral fatigue and on Leg(2) immediately following Leg(1) (Leg(2-CONTRA)). The tests were completed following ingestion of 1-g ACT or maltodextrin [placebo (PL)] capsules. Intramuscular phosphorus-containing metabolites and substrates and muscle activation were assessed using (31)P-MRS and electromyography, respectively. T(lim) was not different between Leg(1ACT) and Leg(1PL) conditions (402 ± 101 vs. 390 ± 106 s, P = 0.11). There was also no difference in T(lim) between Leg(2ACT-CONTRA) and Leg(2PL-CONTRA) (324 ± 85 vs. 311 ± 92 s, P = 0.10), but T(lim) was shorter in Leg(2ACT-CONTRA) and Leg(2PL-CONTRA) than in Leg(2CON) (385 ± 104 s, both P < 0.05). There were no differences in intramuscular phosphorus-containing metabolites and substrates or muscle activation between Leg(1ACT) and Leg(1PL) and between Leg(2ACT-CONTRA) and Leg(2PL-CONTRA) (all P > 0.05). These findings suggest that levels of metabolic perturbation and muscle activation at T(lim) are not different during single-leg severe-intensity knee-extensor exercise completed with or without prior fatiguing exercise of the contralateral leg. Despite contralateral fatigue, ACT ingestion did not alter neuromuscular responses, muscle metabolites, or exercise performance.
format Online
Article
Text
id pubmed-6732432
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher American Physiological Society
record_format MEDLINE/PubMed
spelling pubmed-67324322019-09-10 Contralateral fatigue during severe-intensity single-leg exercise: influence of acute acetaminophen ingestion Morgan, Paul T. Bailey, Stephen J. Banks, Rhys A. Fulford, Jonathan Vanhatalo, Anni Jones, Andrew M. Am J Physiol Regul Integr Comp Physiol Research Article Exhaustive single-leg exercise has been suggested to reduce time to task failure (T(lim)) during subsequent exercise in the contralateral leg by exacerbating central fatigue development. We investigated the influence of acetaminophen (ACT), an analgesic that may blunt central fatigue development, on T(lim) during single-leg exercise completed with and without prior fatiguing exercise of the contralateral leg. Fourteen recreationally active men performed single-leg severe-intensity knee-extensor exercise to T(lim) on the left (Leg(1)) and right (Leg(2)) legs without prior contralateral fatigue and on Leg(2) immediately following Leg(1) (Leg(2-CONTRA)). The tests were completed following ingestion of 1-g ACT or maltodextrin [placebo (PL)] capsules. Intramuscular phosphorus-containing metabolites and substrates and muscle activation were assessed using (31)P-MRS and electromyography, respectively. T(lim) was not different between Leg(1ACT) and Leg(1PL) conditions (402 ± 101 vs. 390 ± 106 s, P = 0.11). There was also no difference in T(lim) between Leg(2ACT-CONTRA) and Leg(2PL-CONTRA) (324 ± 85 vs. 311 ± 92 s, P = 0.10), but T(lim) was shorter in Leg(2ACT-CONTRA) and Leg(2PL-CONTRA) than in Leg(2CON) (385 ± 104 s, both P < 0.05). There were no differences in intramuscular phosphorus-containing metabolites and substrates or muscle activation between Leg(1ACT) and Leg(1PL) and between Leg(2ACT-CONTRA) and Leg(2PL-CONTRA) (all P > 0.05). These findings suggest that levels of metabolic perturbation and muscle activation at T(lim) are not different during single-leg severe-intensity knee-extensor exercise completed with or without prior fatiguing exercise of the contralateral leg. Despite contralateral fatigue, ACT ingestion did not alter neuromuscular responses, muscle metabolites, or exercise performance. American Physiological Society 2019-08-01 2019-05-29 /pmc/articles/PMC6732432/ /pubmed/31141387 http://dx.doi.org/10.1152/ajpregu.00084.2019 Text en Copyright © 2019 the American Physiological Society http://creativecommons.org/licenses/by/4.0/deed.en_US Licensed under Creative Commons Attribution CC-BY 4.0 (http://creativecommons.org/licenses/by/4.0/deed.en_US) : © the American Physiological Society.
spellingShingle Research Article
Morgan, Paul T.
Bailey, Stephen J.
Banks, Rhys A.
Fulford, Jonathan
Vanhatalo, Anni
Jones, Andrew M.
Contralateral fatigue during severe-intensity single-leg exercise: influence of acute acetaminophen ingestion
title Contralateral fatigue during severe-intensity single-leg exercise: influence of acute acetaminophen ingestion
title_full Contralateral fatigue during severe-intensity single-leg exercise: influence of acute acetaminophen ingestion
title_fullStr Contralateral fatigue during severe-intensity single-leg exercise: influence of acute acetaminophen ingestion
title_full_unstemmed Contralateral fatigue during severe-intensity single-leg exercise: influence of acute acetaminophen ingestion
title_short Contralateral fatigue during severe-intensity single-leg exercise: influence of acute acetaminophen ingestion
title_sort contralateral fatigue during severe-intensity single-leg exercise: influence of acute acetaminophen ingestion
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6732432/
https://www.ncbi.nlm.nih.gov/pubmed/31141387
http://dx.doi.org/10.1152/ajpregu.00084.2019
work_keys_str_mv AT morganpault contralateralfatigueduringsevereintensitysinglelegexerciseinfluenceofacuteacetaminopheningestion
AT baileystephenj contralateralfatigueduringsevereintensitysinglelegexerciseinfluenceofacuteacetaminopheningestion
AT banksrhysa contralateralfatigueduringsevereintensitysinglelegexerciseinfluenceofacuteacetaminopheningestion
AT fulfordjonathan contralateralfatigueduringsevereintensitysinglelegexerciseinfluenceofacuteacetaminopheningestion
AT vanhataloanni contralateralfatigueduringsevereintensitysinglelegexerciseinfluenceofacuteacetaminopheningestion
AT jonesandrewm contralateralfatigueduringsevereintensitysinglelegexerciseinfluenceofacuteacetaminopheningestion