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Exploring the Pathological Mechanism of Bladder Cancer Based on Tumor Mutational Burden Analysis

Although immunotherapy has progressed in the treatment of bladder cancer, some patients still have poor prognosis. New therapeutic targets are eager to be discovered to improve the outcomes of bladder cancer. With the development of high-throughput sequencing and tumor profiling, potential tumor bio...

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Detalles Bibliográficos
Autores principales: Ma, Yao, Feng, Xiao-Fei, Yang, Wan-Xia, You, Chong-Ge
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6732589/
https://www.ncbi.nlm.nih.gov/pubmed/31534952
http://dx.doi.org/10.1155/2019/1093815
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author Ma, Yao
Feng, Xiao-Fei
Yang, Wan-Xia
You, Chong-Ge
author_facet Ma, Yao
Feng, Xiao-Fei
Yang, Wan-Xia
You, Chong-Ge
author_sort Ma, Yao
collection PubMed
description Although immunotherapy has progressed in the treatment of bladder cancer, some patients still have poor prognosis. New therapeutic targets are eager to be discovered to improve the outcomes of bladder cancer. With the development of high-throughput sequencing and tumor profiling, potential tumor biomarkers were identified. Through the interpretation of related data from the Cancer Genome Atlas database (TCGA), some key genes have been discovered to drive the development and prognosis of urinary bladder neoplasm. On account of the success of immunotherapy in many cancer types, we established the relationship between tumor mutation burden and immune microenvironment of bladder cancer and found the changes of several immune cells in this disease. Based on the understanding of the bladder tumor genome and immune environment, this study is supposed to provide new therapies for the treatment of bladder neoplasm.
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spelling pubmed-67325892019-09-18 Exploring the Pathological Mechanism of Bladder Cancer Based on Tumor Mutational Burden Analysis Ma, Yao Feng, Xiao-Fei Yang, Wan-Xia You, Chong-Ge Biomed Res Int Research Article Although immunotherapy has progressed in the treatment of bladder cancer, some patients still have poor prognosis. New therapeutic targets are eager to be discovered to improve the outcomes of bladder cancer. With the development of high-throughput sequencing and tumor profiling, potential tumor biomarkers were identified. Through the interpretation of related data from the Cancer Genome Atlas database (TCGA), some key genes have been discovered to drive the development and prognosis of urinary bladder neoplasm. On account of the success of immunotherapy in many cancer types, we established the relationship between tumor mutation burden and immune microenvironment of bladder cancer and found the changes of several immune cells in this disease. Based on the understanding of the bladder tumor genome and immune environment, this study is supposed to provide new therapies for the treatment of bladder neoplasm. Hindawi 2019-08-25 /pmc/articles/PMC6732589/ /pubmed/31534952 http://dx.doi.org/10.1155/2019/1093815 Text en Copyright © 2019 Yao Ma et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Ma, Yao
Feng, Xiao-Fei
Yang, Wan-Xia
You, Chong-Ge
Exploring the Pathological Mechanism of Bladder Cancer Based on Tumor Mutational Burden Analysis
title Exploring the Pathological Mechanism of Bladder Cancer Based on Tumor Mutational Burden Analysis
title_full Exploring the Pathological Mechanism of Bladder Cancer Based on Tumor Mutational Burden Analysis
title_fullStr Exploring the Pathological Mechanism of Bladder Cancer Based on Tumor Mutational Burden Analysis
title_full_unstemmed Exploring the Pathological Mechanism of Bladder Cancer Based on Tumor Mutational Burden Analysis
title_short Exploring the Pathological Mechanism of Bladder Cancer Based on Tumor Mutational Burden Analysis
title_sort exploring the pathological mechanism of bladder cancer based on tumor mutational burden analysis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6732589/
https://www.ncbi.nlm.nih.gov/pubmed/31534952
http://dx.doi.org/10.1155/2019/1093815
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