Vigabatrin-Induced Encephalopathy in a 5.5-Month-Old Girl with Infantile Spasms due to Tuberous Sclerosis

A 5.5-month-old female infant with tuberous sclerosis complex presented with infantile spasms and was treated with vigabatrin. As her condition did not improve, she was given adrenocorticotropic hormone (ACTH) intramuscularly which stopped the spasms and improved the electroencephalogram (EEG) abnor...

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Autores principales: Klinaki, Eleni, Argyri, Ioanna, Amountza, Georgia, Ioannidou, Gerina, Maritsi, Despoina, Garoufi, Anastasia, Vartzelis, George
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6732644/
https://www.ncbi.nlm.nih.gov/pubmed/31534811
http://dx.doi.org/10.1155/2019/7249237
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author Klinaki, Eleni
Argyri, Ioanna
Amountza, Georgia
Ioannidou, Gerina
Maritsi, Despoina
Garoufi, Anastasia
Vartzelis, George
author_facet Klinaki, Eleni
Argyri, Ioanna
Amountza, Georgia
Ioannidou, Gerina
Maritsi, Despoina
Garoufi, Anastasia
Vartzelis, George
author_sort Klinaki, Eleni
collection PubMed
description A 5.5-month-old female infant with tuberous sclerosis complex presented with infantile spasms and was treated with vigabatrin. As her condition did not improve, she was given adrenocorticotropic hormone (ACTH) intramuscularly which stopped the spasms and improved the electroencephalogram (EEG) abnormalities. However, she developed encephalopathy with apathy, drowsiness, and generalized slowing in the EEG. Discontinuation of vigabatrin quickly improved her symptoms and reversed the EEG slowing. A high index of suspicion is required in order to diagnose vigabatrin-induced encephalopathy, especially as the underlying disorders of these patients can be erroneously considered the cause of the observed encephalopathy.
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spelling pubmed-67326442019-09-18 Vigabatrin-Induced Encephalopathy in a 5.5-Month-Old Girl with Infantile Spasms due to Tuberous Sclerosis Klinaki, Eleni Argyri, Ioanna Amountza, Georgia Ioannidou, Gerina Maritsi, Despoina Garoufi, Anastasia Vartzelis, George Case Rep Pediatr Case Report A 5.5-month-old female infant with tuberous sclerosis complex presented with infantile spasms and was treated with vigabatrin. As her condition did not improve, she was given adrenocorticotropic hormone (ACTH) intramuscularly which stopped the spasms and improved the electroencephalogram (EEG) abnormalities. However, she developed encephalopathy with apathy, drowsiness, and generalized slowing in the EEG. Discontinuation of vigabatrin quickly improved her symptoms and reversed the EEG slowing. A high index of suspicion is required in order to diagnose vigabatrin-induced encephalopathy, especially as the underlying disorders of these patients can be erroneously considered the cause of the observed encephalopathy. Hindawi 2019-08-25 /pmc/articles/PMC6732644/ /pubmed/31534811 http://dx.doi.org/10.1155/2019/7249237 Text en Copyright © 2019 Eleni Klinaki et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Klinaki, Eleni
Argyri, Ioanna
Amountza, Georgia
Ioannidou, Gerina
Maritsi, Despoina
Garoufi, Anastasia
Vartzelis, George
Vigabatrin-Induced Encephalopathy in a 5.5-Month-Old Girl with Infantile Spasms due to Tuberous Sclerosis
title Vigabatrin-Induced Encephalopathy in a 5.5-Month-Old Girl with Infantile Spasms due to Tuberous Sclerosis
title_full Vigabatrin-Induced Encephalopathy in a 5.5-Month-Old Girl with Infantile Spasms due to Tuberous Sclerosis
title_fullStr Vigabatrin-Induced Encephalopathy in a 5.5-Month-Old Girl with Infantile Spasms due to Tuberous Sclerosis
title_full_unstemmed Vigabatrin-Induced Encephalopathy in a 5.5-Month-Old Girl with Infantile Spasms due to Tuberous Sclerosis
title_short Vigabatrin-Induced Encephalopathy in a 5.5-Month-Old Girl with Infantile Spasms due to Tuberous Sclerosis
title_sort vigabatrin-induced encephalopathy in a 5.5-month-old girl with infantile spasms due to tuberous sclerosis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6732644/
https://www.ncbi.nlm.nih.gov/pubmed/31534811
http://dx.doi.org/10.1155/2019/7249237
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