Metabolic engineering of Bacillus amyloliquefaciens for enhanced production of S-adenosylmethionine by coupling of an engineered S-adenosylmethionine pathway and the tricarboxylic acid cycle

BACKGROUND: S-Adenosylmethionine (SAM) is a critical cofactor involved in many biochemical reactions. However, the low fermentation titer of SAM in methionine-free medium hampers commercial-scale production. The SAM synthesis pathway is specially related to the tricarboxylic acid (TCA) cycle in Baci...

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Detalles Bibliográficos
Autores principales: Ruan, Liying, Li, Lu, Zou, Dian, Jiang, Cong, Wen, Zhiyou, Chen, Shouwen, Deng, Yu, Wei, Xuetuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6732833/
https://www.ncbi.nlm.nih.gov/pubmed/31516550
http://dx.doi.org/10.1186/s13068-019-1554-0

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