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Primary hematological malignancy of the uterine cervix: A case report

The present case report investigated the clinical characteristics of primary hematological malignancy of the uterine cervixin five patients. Among the five patients, three patients were diagnosed with non-Hodgkin's lymphoma (NHL) and two patients with myeloid sarcoma (MS) of the uterine cervix....

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Autores principales: Gui, Wei, Li, Jing, Zhang, Zong, Wang, Lieyang, Zhao, Jin, Ma, Li, Su, Liping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6732943/
https://www.ncbi.nlm.nih.gov/pubmed/31516559
http://dx.doi.org/10.3892/ol.2019.10652
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author Gui, Wei
Li, Jing
Zhang, Zong
Wang, Lieyang
Zhao, Jin
Ma, Li
Su, Liping
author_facet Gui, Wei
Li, Jing
Zhang, Zong
Wang, Lieyang
Zhao, Jin
Ma, Li
Su, Liping
author_sort Gui, Wei
collection PubMed
description The present case report investigated the clinical characteristics of primary hematological malignancy of the uterine cervixin five patients. Among the five patients, three patients were diagnosed with non-Hodgkin's lymphoma (NHL) and two patients with myeloid sarcoma (MS) of the uterine cervix. Biopsies of the uterine cervices demonstrated the involvement of lymphoid cells or myeloid blasts cells. Immunohistochemical staining demonstrated the expression of B-lymphoid and myeloid lineage markers. The associated lysozyme, myeloperoxidase and mast/stem cell growth factor receptor (CD117) markers were specific for the diagnosis of MS. The three patients with NHL survived, and one of the patients survived for 82 months with no evidence of disease; however, was eventually lost to follow-up. The two patients with MS succumbed to the cancer as a result of progressive disease and leukemia. Therefore, pathological examination may be important for the timely diagnosis and appropriate therapeutic regimen for primary hematological malignancy of the uterine cervix.
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spelling pubmed-67329432019-09-12 Primary hematological malignancy of the uterine cervix: A case report Gui, Wei Li, Jing Zhang, Zong Wang, Lieyang Zhao, Jin Ma, Li Su, Liping Oncol Lett Articles The present case report investigated the clinical characteristics of primary hematological malignancy of the uterine cervixin five patients. Among the five patients, three patients were diagnosed with non-Hodgkin's lymphoma (NHL) and two patients with myeloid sarcoma (MS) of the uterine cervix. Biopsies of the uterine cervices demonstrated the involvement of lymphoid cells or myeloid blasts cells. Immunohistochemical staining demonstrated the expression of B-lymphoid and myeloid lineage markers. The associated lysozyme, myeloperoxidase and mast/stem cell growth factor receptor (CD117) markers were specific for the diagnosis of MS. The three patients with NHL survived, and one of the patients survived for 82 months with no evidence of disease; however, was eventually lost to follow-up. The two patients with MS succumbed to the cancer as a result of progressive disease and leukemia. Therefore, pathological examination may be important for the timely diagnosis and appropriate therapeutic regimen for primary hematological malignancy of the uterine cervix. D.A. Spandidos 2019-09 2019-07-22 /pmc/articles/PMC6732943/ /pubmed/31516559 http://dx.doi.org/10.3892/ol.2019.10652 Text en Copyright: © Gui et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Gui, Wei
Li, Jing
Zhang, Zong
Wang, Lieyang
Zhao, Jin
Ma, Li
Su, Liping
Primary hematological malignancy of the uterine cervix: A case report
title Primary hematological malignancy of the uterine cervix: A case report
title_full Primary hematological malignancy of the uterine cervix: A case report
title_fullStr Primary hematological malignancy of the uterine cervix: A case report
title_full_unstemmed Primary hematological malignancy of the uterine cervix: A case report
title_short Primary hematological malignancy of the uterine cervix: A case report
title_sort primary hematological malignancy of the uterine cervix: a case report
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6732943/
https://www.ncbi.nlm.nih.gov/pubmed/31516559
http://dx.doi.org/10.3892/ol.2019.10652
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