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Viscosine as a Potent and Safe Antipyretic Agent Evaluated by Yeast-Induced Pyrexia Model and Molecular Docking Studies

[Image: see text] The antipyretic potential of viscosine, a natural product isolated from the medicinal plant Dodonaea viscosa, was investigated using yeast-induced pyrexia rat model, and its structure–activity relationship was investigated through molecular docking analyses with the target enzymes...

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Autores principales: Muhammad, Akhtar, Khan, Behramand, Iqbal, Zafar, Khan, Amir Zada, Khan, Inamullah, Khan, Kashif, Alamzeb, Muhammad, Ahmad, Nasir, Khan, Khalid, Lal Badshah, Syed, Ullah, Asad, Muhammad, Sayyar, Jan, Muhammad Tariq, Nadeem, Said, Kabir, Nurul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6732982/
https://www.ncbi.nlm.nih.gov/pubmed/31508540
http://dx.doi.org/10.1021/acsomega.9b01041
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author Muhammad, Akhtar
Khan, Behramand
Iqbal, Zafar
Khan, Amir Zada
Khan, Inamullah
Khan, Kashif
Alamzeb, Muhammad
Ahmad, Nasir
Khan, Khalid
Lal Badshah, Syed
Ullah, Asad
Muhammad, Sayyar
Jan, Muhammad Tariq
Nadeem, Said
Kabir, Nurul
author_facet Muhammad, Akhtar
Khan, Behramand
Iqbal, Zafar
Khan, Amir Zada
Khan, Inamullah
Khan, Kashif
Alamzeb, Muhammad
Ahmad, Nasir
Khan, Khalid
Lal Badshah, Syed
Ullah, Asad
Muhammad, Sayyar
Jan, Muhammad Tariq
Nadeem, Said
Kabir, Nurul
author_sort Muhammad, Akhtar
collection PubMed
description [Image: see text] The antipyretic potential of viscosine, a natural product isolated from the medicinal plant Dodonaea viscosa, was investigated using yeast-induced pyrexia rat model, and its structure–activity relationship was investigated through molecular docking analyses with the target enzymes cyclooxygenase-1 (COX-1), cyclooxygenase-2 (COX-2), and microsomal prostaglandin E synthase-1 (mPGES-1). The in vivo antipyretic experiments showed a progressive dose-dependent reduction in body temperatures of the hyperthermic test animals when injected with viscosine. Comparison of docking analyses with target enzymes showed strongest bonding interactions (binding energy −17.34 kcal/mol) of viscosine with the active-site pocket of mPGES-1. These findings suggest that viscosine shows antipyretic properties by reducing the concentration of prostaglandin E(2) in brain through its mPGES-1 inhibitory action and make it a potential lead compound for developing effective and safer antipyretic drugs for treating fever and related pathological conditions.
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spelling pubmed-67329822019-09-10 Viscosine as a Potent and Safe Antipyretic Agent Evaluated by Yeast-Induced Pyrexia Model and Molecular Docking Studies Muhammad, Akhtar Khan, Behramand Iqbal, Zafar Khan, Amir Zada Khan, Inamullah Khan, Kashif Alamzeb, Muhammad Ahmad, Nasir Khan, Khalid Lal Badshah, Syed Ullah, Asad Muhammad, Sayyar Jan, Muhammad Tariq Nadeem, Said Kabir, Nurul ACS Omega [Image: see text] The antipyretic potential of viscosine, a natural product isolated from the medicinal plant Dodonaea viscosa, was investigated using yeast-induced pyrexia rat model, and its structure–activity relationship was investigated through molecular docking analyses with the target enzymes cyclooxygenase-1 (COX-1), cyclooxygenase-2 (COX-2), and microsomal prostaglandin E synthase-1 (mPGES-1). The in vivo antipyretic experiments showed a progressive dose-dependent reduction in body temperatures of the hyperthermic test animals when injected with viscosine. Comparison of docking analyses with target enzymes showed strongest bonding interactions (binding energy −17.34 kcal/mol) of viscosine with the active-site pocket of mPGES-1. These findings suggest that viscosine shows antipyretic properties by reducing the concentration of prostaglandin E(2) in brain through its mPGES-1 inhibitory action and make it a potential lead compound for developing effective and safer antipyretic drugs for treating fever and related pathological conditions. American Chemical Society 2019-08-21 /pmc/articles/PMC6732982/ /pubmed/31508540 http://dx.doi.org/10.1021/acsomega.9b01041 Text en Copyright © 2019 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Muhammad, Akhtar
Khan, Behramand
Iqbal, Zafar
Khan, Amir Zada
Khan, Inamullah
Khan, Kashif
Alamzeb, Muhammad
Ahmad, Nasir
Khan, Khalid
Lal Badshah, Syed
Ullah, Asad
Muhammad, Sayyar
Jan, Muhammad Tariq
Nadeem, Said
Kabir, Nurul
Viscosine as a Potent and Safe Antipyretic Agent Evaluated by Yeast-Induced Pyrexia Model and Molecular Docking Studies
title Viscosine as a Potent and Safe Antipyretic Agent Evaluated by Yeast-Induced Pyrexia Model and Molecular Docking Studies
title_full Viscosine as a Potent and Safe Antipyretic Agent Evaluated by Yeast-Induced Pyrexia Model and Molecular Docking Studies
title_fullStr Viscosine as a Potent and Safe Antipyretic Agent Evaluated by Yeast-Induced Pyrexia Model and Molecular Docking Studies
title_full_unstemmed Viscosine as a Potent and Safe Antipyretic Agent Evaluated by Yeast-Induced Pyrexia Model and Molecular Docking Studies
title_short Viscosine as a Potent and Safe Antipyretic Agent Evaluated by Yeast-Induced Pyrexia Model and Molecular Docking Studies
title_sort viscosine as a potent and safe antipyretic agent evaluated by yeast-induced pyrexia model and molecular docking studies
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6732982/
https://www.ncbi.nlm.nih.gov/pubmed/31508540
http://dx.doi.org/10.1021/acsomega.9b01041
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