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Cervical cancer stem cells and other leading factors associated with cervical cancer development
Cervical cancer (CC) is one of the leading causes of cancer-associated mortalities in women from developing countries. Similar to other types of cancer, CC is considered to be a multifactorial disease, involving socioeconomic, cultural, immunological and epigenetic factors, as well as persistent hum...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6733009/ https://www.ncbi.nlm.nih.gov/pubmed/31516560 http://dx.doi.org/10.3892/ol.2019.10718 |
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author | Mendoza-Almanza, Gretel Ortíz-Sánchez, Elizabeth Rocha-Zavaleta, Leticia Rivas-Santiago, César Esparza-Ibarra, Edgar Olmos, Jorge |
author_facet | Mendoza-Almanza, Gretel Ortíz-Sánchez, Elizabeth Rocha-Zavaleta, Leticia Rivas-Santiago, César Esparza-Ibarra, Edgar Olmos, Jorge |
author_sort | Mendoza-Almanza, Gretel |
collection | PubMed |
description | Cervical cancer (CC) is one of the leading causes of cancer-associated mortalities in women from developing countries. Similar to other types of cancer, CC is considered to be a multifactorial disease, involving socioeconomic, cultural, immunological and epigenetic factors, as well as persistent human papilloma virus (HPV) infection. It has been well established that cancer stem cells (CSCs) play an important role in defining tumor size, the speed of development and the level of regression following treatment; therefore, CSCs are associated with a poor prognosis. CSCs have been detected in many types of cancer, including leukemia, pancreatic, colon, esophagus, liver, prostate, breast, gastric and lung cancer. In cervical cancer, CSCs have been associated with resistance to normally used drugs such as cisplatin. The present review summarizes the strategies that high-risk HPV viruses (HPV-16 and HPV-18) have developed to transform normal epithelial cells into cancer cells, as well as the cellular pathways and studies associated with the identification of cervical cancer stem cell biomarkers. In this sense, the present review provides state of the art information regarding CC development. |
format | Online Article Text |
id | pubmed-6733009 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-67330092019-09-12 Cervical cancer stem cells and other leading factors associated with cervical cancer development Mendoza-Almanza, Gretel Ortíz-Sánchez, Elizabeth Rocha-Zavaleta, Leticia Rivas-Santiago, César Esparza-Ibarra, Edgar Olmos, Jorge Oncol Lett Review Cervical cancer (CC) is one of the leading causes of cancer-associated mortalities in women from developing countries. Similar to other types of cancer, CC is considered to be a multifactorial disease, involving socioeconomic, cultural, immunological and epigenetic factors, as well as persistent human papilloma virus (HPV) infection. It has been well established that cancer stem cells (CSCs) play an important role in defining tumor size, the speed of development and the level of regression following treatment; therefore, CSCs are associated with a poor prognosis. CSCs have been detected in many types of cancer, including leukemia, pancreatic, colon, esophagus, liver, prostate, breast, gastric and lung cancer. In cervical cancer, CSCs have been associated with resistance to normally used drugs such as cisplatin. The present review summarizes the strategies that high-risk HPV viruses (HPV-16 and HPV-18) have developed to transform normal epithelial cells into cancer cells, as well as the cellular pathways and studies associated with the identification of cervical cancer stem cell biomarkers. In this sense, the present review provides state of the art information regarding CC development. D.A. Spandidos 2019-10 2019-08-06 /pmc/articles/PMC6733009/ /pubmed/31516560 http://dx.doi.org/10.3892/ol.2019.10718 Text en Copyright: © Mendoza-Almanza et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Review Mendoza-Almanza, Gretel Ortíz-Sánchez, Elizabeth Rocha-Zavaleta, Leticia Rivas-Santiago, César Esparza-Ibarra, Edgar Olmos, Jorge Cervical cancer stem cells and other leading factors associated with cervical cancer development |
title | Cervical cancer stem cells and other leading factors associated with cervical cancer development |
title_full | Cervical cancer stem cells and other leading factors associated with cervical cancer development |
title_fullStr | Cervical cancer stem cells and other leading factors associated with cervical cancer development |
title_full_unstemmed | Cervical cancer stem cells and other leading factors associated with cervical cancer development |
title_short | Cervical cancer stem cells and other leading factors associated with cervical cancer development |
title_sort | cervical cancer stem cells and other leading factors associated with cervical cancer development |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6733009/ https://www.ncbi.nlm.nih.gov/pubmed/31516560 http://dx.doi.org/10.3892/ol.2019.10718 |
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