Synthesis and Antimicrobial Studies of 4-[3-(3-Fluorophenyl)-4-formyl-1H-pyrazol-1-yl]benzoic Acid and 4-[3-(4-Fluorophenyl)-4-formyl-1H-pyrazol-1-yl]benzoic Acid as Potent Growth Inhibitors of Drug-Resistant Bacteria

[Image: see text] Microbial resistance to antibiotics is an urgent and worldwide concern. Several pyrazole-derived hydrazones were synthesized by using benign reaction conditions. Several of these molecules are potent growth inhibitors of drug-resistant strains of Staphylococcus aureus and Acinetoba...

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Autores principales: Whitt, Jedidiah, Duke, Cameron, Ali, Mohamad Akbar, Chambers, Steven A., Khan, Md Mahbub Kabir, Gilmore, David, Alam, Mohammad A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6733178/
https://www.ncbi.nlm.nih.gov/pubmed/31508552
http://dx.doi.org/10.1021/acsomega.9b01967
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author Whitt, Jedidiah
Duke, Cameron
Ali, Mohamad Akbar
Chambers, Steven A.
Khan, Md Mahbub Kabir
Gilmore, David
Alam, Mohammad A.
author_facet Whitt, Jedidiah
Duke, Cameron
Ali, Mohamad Akbar
Chambers, Steven A.
Khan, Md Mahbub Kabir
Gilmore, David
Alam, Mohammad A.
author_sort Whitt, Jedidiah
collection PubMed
description [Image: see text] Microbial resistance to antibiotics is an urgent and worldwide concern. Several pyrazole-derived hydrazones were synthesized by using benign reaction conditions. Several of these molecules are potent growth inhibitors of drug-resistant strains of Staphylococcus aureus and Acinetobacter baumannii with minimum inhibitory concentration values as low as 0.39 μg/mL. Furthermore, these molecules are nontoxic to human cells at high concentrations. Some of these molecules were tested for their ability to disrupt the bacterial membrane by using the SYTO-9/propidium iodide (BacLight) assay.
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spelling pubmed-67331782019-09-10 Synthesis and Antimicrobial Studies of 4-[3-(3-Fluorophenyl)-4-formyl-1H-pyrazol-1-yl]benzoic Acid and 4-[3-(4-Fluorophenyl)-4-formyl-1H-pyrazol-1-yl]benzoic Acid as Potent Growth Inhibitors of Drug-Resistant Bacteria Whitt, Jedidiah Duke, Cameron Ali, Mohamad Akbar Chambers, Steven A. Khan, Md Mahbub Kabir Gilmore, David Alam, Mohammad A. ACS Omega [Image: see text] Microbial resistance to antibiotics is an urgent and worldwide concern. Several pyrazole-derived hydrazones were synthesized by using benign reaction conditions. Several of these molecules are potent growth inhibitors of drug-resistant strains of Staphylococcus aureus and Acinetobacter baumannii with minimum inhibitory concentration values as low as 0.39 μg/mL. Furthermore, these molecules are nontoxic to human cells at high concentrations. Some of these molecules were tested for their ability to disrupt the bacterial membrane by using the SYTO-9/propidium iodide (BacLight) assay. American Chemical Society 2019-08-21 /pmc/articles/PMC6733178/ /pubmed/31508552 http://dx.doi.org/10.1021/acsomega.9b01967 Text en Copyright © 2019 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Whitt, Jedidiah
Duke, Cameron
Ali, Mohamad Akbar
Chambers, Steven A.
Khan, Md Mahbub Kabir
Gilmore, David
Alam, Mohammad A.
Synthesis and Antimicrobial Studies of 4-[3-(3-Fluorophenyl)-4-formyl-1H-pyrazol-1-yl]benzoic Acid and 4-[3-(4-Fluorophenyl)-4-formyl-1H-pyrazol-1-yl]benzoic Acid as Potent Growth Inhibitors of Drug-Resistant Bacteria
title Synthesis and Antimicrobial Studies of 4-[3-(3-Fluorophenyl)-4-formyl-1H-pyrazol-1-yl]benzoic Acid and 4-[3-(4-Fluorophenyl)-4-formyl-1H-pyrazol-1-yl]benzoic Acid as Potent Growth Inhibitors of Drug-Resistant Bacteria
title_full Synthesis and Antimicrobial Studies of 4-[3-(3-Fluorophenyl)-4-formyl-1H-pyrazol-1-yl]benzoic Acid and 4-[3-(4-Fluorophenyl)-4-formyl-1H-pyrazol-1-yl]benzoic Acid as Potent Growth Inhibitors of Drug-Resistant Bacteria
title_fullStr Synthesis and Antimicrobial Studies of 4-[3-(3-Fluorophenyl)-4-formyl-1H-pyrazol-1-yl]benzoic Acid and 4-[3-(4-Fluorophenyl)-4-formyl-1H-pyrazol-1-yl]benzoic Acid as Potent Growth Inhibitors of Drug-Resistant Bacteria
title_full_unstemmed Synthesis and Antimicrobial Studies of 4-[3-(3-Fluorophenyl)-4-formyl-1H-pyrazol-1-yl]benzoic Acid and 4-[3-(4-Fluorophenyl)-4-formyl-1H-pyrazol-1-yl]benzoic Acid as Potent Growth Inhibitors of Drug-Resistant Bacteria
title_short Synthesis and Antimicrobial Studies of 4-[3-(3-Fluorophenyl)-4-formyl-1H-pyrazol-1-yl]benzoic Acid and 4-[3-(4-Fluorophenyl)-4-formyl-1H-pyrazol-1-yl]benzoic Acid as Potent Growth Inhibitors of Drug-Resistant Bacteria
title_sort synthesis and antimicrobial studies of 4-[3-(3-fluorophenyl)-4-formyl-1h-pyrazol-1-yl]benzoic acid and 4-[3-(4-fluorophenyl)-4-formyl-1h-pyrazol-1-yl]benzoic acid as potent growth inhibitors of drug-resistant bacteria
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6733178/
https://www.ncbi.nlm.nih.gov/pubmed/31508552
http://dx.doi.org/10.1021/acsomega.9b01967
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