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The mechanism: how dental resorptions occur in ameloblastoma

Knife-edge or blunt root resorptions characterize ameloblastomas and are pathognomonic for this tumor, because they differentiate ameloblastomas from simple bone cysts, odontogenic keratocysts and nasopalatine duct cysts, which do not lead to resorption of involved teeth. Despite the very high frequ...

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Detalles Bibliográficos
Autores principales: Martins, Giovana Gonçalves, de Oliveira, Ingrid Araújo, Consolaro, Alberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dental Press International 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6733230/
https://www.ncbi.nlm.nih.gov/pubmed/31508703
http://dx.doi.org/10.1590/2177-6709.24.4.021-032.oin
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author Martins, Giovana Gonçalves
de Oliveira, Ingrid Araújo
Consolaro, Alberto
author_facet Martins, Giovana Gonçalves
de Oliveira, Ingrid Araújo
Consolaro, Alberto
author_sort Martins, Giovana Gonçalves
collection PubMed
description Knife-edge or blunt root resorptions characterize ameloblastomas and are pathognomonic for this tumor, because they differentiate ameloblastomas from simple bone cysts, odontogenic keratocysts and nasopalatine duct cysts, which do not lead to resorption of involved teeth. Despite the very high frequency and importance of these characteristics for a differential diagnosis, a microscopic examination should also be conducted before defining the diagnosis and the treatment plan for these cases. This paper describes a six-step hypothesis to explain the mechanism by which ameloblastomas promote the characteristic root resorptions found in association with these benign epithelial tumors, which have a fibrous capsule formed by islands and epithelial cords that mimic the dental lamina, invade neighboring tissues and release mediators (IL-1, EGF) of tooth and root resorption. This hypothesis may be one more explanation for the tooth resorptions sometimes found in orthodontic records, and may help differentiate the root resorptions that are specific to the orthodontic practice.
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spelling pubmed-67332302019-09-13 The mechanism: how dental resorptions occur in ameloblastoma Martins, Giovana Gonçalves de Oliveira, Ingrid Araújo Consolaro, Alberto Dental Press J Orthod Orthodontic Insight Knife-edge or blunt root resorptions characterize ameloblastomas and are pathognomonic for this tumor, because they differentiate ameloblastomas from simple bone cysts, odontogenic keratocysts and nasopalatine duct cysts, which do not lead to resorption of involved teeth. Despite the very high frequency and importance of these characteristics for a differential diagnosis, a microscopic examination should also be conducted before defining the diagnosis and the treatment plan for these cases. This paper describes a six-step hypothesis to explain the mechanism by which ameloblastomas promote the characteristic root resorptions found in association with these benign epithelial tumors, which have a fibrous capsule formed by islands and epithelial cords that mimic the dental lamina, invade neighboring tissues and release mediators (IL-1, EGF) of tooth and root resorption. This hypothesis may be one more explanation for the tooth resorptions sometimes found in orthodontic records, and may help differentiate the root resorptions that are specific to the orthodontic practice. Dental Press International 2019 /pmc/articles/PMC6733230/ /pubmed/31508703 http://dx.doi.org/10.1590/2177-6709.24.4.021-032.oin Text en https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License
spellingShingle Orthodontic Insight
Martins, Giovana Gonçalves
de Oliveira, Ingrid Araújo
Consolaro, Alberto
The mechanism: how dental resorptions occur in ameloblastoma
title The mechanism: how dental resorptions occur in ameloblastoma
title_full The mechanism: how dental resorptions occur in ameloblastoma
title_fullStr The mechanism: how dental resorptions occur in ameloblastoma
title_full_unstemmed The mechanism: how dental resorptions occur in ameloblastoma
title_short The mechanism: how dental resorptions occur in ameloblastoma
title_sort mechanism: how dental resorptions occur in ameloblastoma
topic Orthodontic Insight
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6733230/
https://www.ncbi.nlm.nih.gov/pubmed/31508703
http://dx.doi.org/10.1590/2177-6709.24.4.021-032.oin
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