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Observation of high-temperature macromolecular confinement in lyophilised protein formulations using terahertz spectroscopy

Characterising the structural dynamics of proteins and the effects of excipients are critical for optimising the design of formulations. In this work we investigated four lyophilised formulations containing bovine serum albumin (BSA) and three formulations containing a monoclonal antibody (mAb, here...

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Detalles Bibliográficos
Autores principales:	Shmool, Talia A., Woodhams, P.J., Leutzsch, Markus, Stephens, Amberley D., Gaimann, Mario U., Mantle, Michael D., Kaminski Schierle, Gabriele S., van der Walle, Christopher F., Zeitler, J. Axel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6733290/ https://www.ncbi.nlm.nih.gov/pubmed/31517287 http://dx.doi.org/10.1016/j.ijpx.2019.100022

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