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Preclinical evaluation of topically-administered PEGylated Fab’ lung toxicity

PEGylation is a promising approach to increase the residence time of antibody fragments in the lungs and sustain their therapeutic effects. However, concerns arise as to the potential pulmonary toxicity of antibody fragments conjugated to high molecular weight (HMW) polyethylene glycol (PEG), notabl...

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Detalles Bibliográficos
Autores principales:	Freches, Danielle, Rocks, Natacha, Patil, Harshad P., Perin, Fabienne, Van Snick, Jacques, Vanbever, Rita, Cataldo, Didier
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6733299/ https://www.ncbi.nlm.nih.gov/pubmed/31517284 http://dx.doi.org/10.1016/j.ijpx.2019.100019

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