Cargando…

Analysis of serious adverse events in a paediatric fast breathing pneumonia clinical trial in Malawi

INTRODUCTION: Pneumonia is the leading infectious killer of children. We conducted a double-blind, randomised controlled non-inferiority trial comparing placebo to amoxicillin treatment for fast breathing pneumonia in HIV-negative children aged 2–59 months in Malawi. Occurrence of serious adverse ev...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nkwopara, Evangelyn, Schmicker, Robert, Mvalo, Tisungane, Phiri, Melda, Phiri, Ajib, Couasnon, Mari, McCollum, Eric D., Ginsburg, Amy Sarah
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2019
Materias:	Paediatric Lung Disease
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6733335/ https://www.ncbi.nlm.nih.gov/pubmed/31548894 http://dx.doi.org/10.1136/bmjresp-2019-000415

Ejemplares similares

Geographically linked risk factors for enrolment into a fast breathing child pneumonia trial in Lilongwe, Malawi: an Innovative Treatments in Pneumonia (ITIP) secondary analysis
por: Nkwopara, Evangelyn, et al.
Publicado: (2019)

Repeat assessment of examination signs among children in Malawi with fast-breathing pneumonia
por: Lenahan, Jennifer L., et al.
Publicado: (2020)

Placebo vs Amoxicillin for Nonsevere Fast-Breathing Pneumonia in Malawian Children Aged 2 to 59 Months: A Double-blind, Randomized Clinical Noninferiority Trial
por: Ginsburg, Amy Sarah, et al.
Publicado: (2018)

Malawian children with fast-breathing pneumonia with and without comorbidities
por: Ginsburg, Amy Sarah, et al.
Publicado: (2021)

Clinical Outcomes of Pneumonia and Other Comorbidities in Children Aged 2-59 Months in Lilongwe, Malawi: Protocol for the Prospective Observational Study “Innovative Treatments in Pneumonia”
por: Ginsburg, Amy Sarah, et al.
Publicado: (2019)

Title Correction: Clinical Outcomes of Pneumonia and Other Comorbidities in Children Aged 2-59 Months in Lilongwe, Malawi: Protocol for the Prospective Observational Study “Innovative Treatments in Pneumonia”
por: Ginsburg, Amy Sarah, et al.
Publicado: (2019)

Amoxicillin 3 vs 5 days for chest-indrawing pneumonia in Malawian children
por: Ginsburg, Amy Sarah, et al.
Publicado: (2020)

Chest radiography in children aged 2–59 months enrolled in the Innovative Treatments in Pneumonia (ITIP) project in Lilongwe Malawi: a secondary analysis
por: Mvalo, Tisungane, et al.
Publicado: (2022)

Methods for conducting a double-blind randomized controlled clinical trial of three days versus five days of amoxicillin dispersible tablets for chest indrawing childhood pneumonia among children two to 59 months of age in Lilongwe, Malawi: a study protocol
por: Ginsburg, Amy Sarah, et al.
Publicado: (2018)

Development of a prognostic risk score to aid antibiotic decision-making for children aged 2-59 months with World Health Organization fast breathing pneumonia in Malawi: An Innovative Treatments in Pneumonia (ITIP) secondary analysis
por: McCollum, Eric D., et al.
Publicado: (2019)

CPAP IMPACT: a protocol for a randomised trial of bubble continuous positive airway pressure versus standard care for high-risk children with severe pneumonia using adaptive design methods
por: Smith, Andrew G, et al.
Publicado: (2017)

Focus group discussions on low-flow oxygen and bubble CPAP treatments among mothers of young children in Malawi: a CPAP IMPACT substudy
por: Sessions, Kristen L, et al.
Publicado: (2020)

Identifying modifiable risk factors for mortality in children aged 1–59 months admitted with WHO-defined severe pneumonia: a single-centre observational cohort study from rural Malawi
por: Eckerle, Michelle, et al.
Publicado: (2022)

Defining hypoxaemia from pulse oximeter measurements of oxygen saturation in well children at low altitude in Bangladesh: an observational study
por: McCollum, Eric D, et al.
Publicado: (2021)

Non-treatment of children with community health worker-diagnosed fast-breathing pneumonia in rural Malawi: exploratory subanalysis of a prospective cohort study
por: King, Carina, et al.
Publicado: (2016)

Altered breathing mechanics and ventilatory response during exercise in children born extremely preterm
por: MacLean, J E, et al.
Publicado: (2016)

Evaluation of non-invasive continuous physiological monitoring devices for neonates in Nairobi, Kenya: a research protocol
por: Ginsburg, Amy Sarah, et al.
Publicado: (2020)

Listening panel agreement and characteristics of lung sounds digitally recorded from children aged 1–59 months enrolled in the Pneumonia Etiology Research for Child Health (PERCH) case–control study
por: McCollum, Eric D, et al.
Publicado: (2017)

Chest radiograph reading panel performance in a Bangladesh pneumococcal vaccine effectiveness study
por: McCollum, Eric D, et al.
Publicado: (2019)

Digitally recorded and remotely classified lung auscultation compared with conventional stethoscope classifications among children aged 1–59 months enrolled in the Pneumonia Etiology Research for Child Health (PERCH) case–control study
por: Park, Daniel E, et al.
Publicado: (2022)

Malawian children with chest-indrawing pneumonia with and without comorbidities or danger signs
por: Ginsburg, Amy Sarah, et al.
Publicado: (2021)

Relationship of proteinases and proteinase inhibitors with microbial presence in chronic lung disease of prematurity
por: Davies, Philip L, et al.
Publicado: (2010)

Neutrophil TLR4 expression is reduced in the airways of infants with severe bronchiolitis
por: Halfhide, C P, et al.
Publicado: (2009)

SABRE: a multicentre randomised control trial of nebulised hypertonic saline in infants hospitalised with acute bronchiolitis
por: Everard, Mark L, et al.
Publicado: (2014)

Perinatal paracetamol exposure in mice does not affect the development of allergic airways disease in early life
por: Lee, Debbie C P, et al.
Publicado: (2015)

Effect of idiopathic thoracic scoliosis on the tracheobronchial tree
por: Farrell, James, et al.
Publicado: (2018)

Determinants of early-life lung function in African infants
por: Gray, Diane, et al.
Publicado: (2017)

‘Dry’ and ‘wet’ cough: how reliable is parental reporting?
por: Donnelly, Deirdre, et al.
Publicado: (2019)

Lung health and exposure to air pollution in Malawian children (CAPS): a cross-sectional study
por: Rylance, Sarah, et al.
Publicado: (2019)

Effect of acute respiratory infections in infancy on pulmonary function test at 3 years of age: a prospective birth cohort study
por: Kumar, Prawin, et al.
Publicado: (2020)

Efficacy and safety of high flow nasal oxygen for children with bronchiolitis: systematic review and meta-analysis
por: Dafydd, Carwyn, et al.
Publicado: (2021)

Asthma, atopy and lung function in young adults after hospitalisation for bronchiolitis in infancy: impact of virus and sex
por: Sørensen, Karen Galta, et al.
Publicado: (2022)

Genomic testing for children with interstitial and diffuse lung disease (chILD): parent satisfaction, understanding and health-related quality of life
por: Kelada, Lauren, et al.
Publicado: (2022)

Association of the dysfunctional placentation endotype of prematurity with bronchopulmonary dysplasia: a systematic review, meta-analysis and meta-regression
por: Pierro, Maria, et al.
Publicado: (2022)

New method to measure interbreath intervals in infants for the assessment of apnoea and respiration
por: Adjei, Tricia, et al.
Publicado: (2021)

MRI of the upper airways in children and young adults: the MUSIC study
por: Elders, Bernadette, et al.
Publicado: (2021)

Air quality, Environment and Respiratory Outcomes in Bronchopulmonary Dysplasia, the AERO-BPD cohort study: design and adaptation during the SARS-CoV-2 pandemic
por: Ruran, Hana B, et al.
Publicado: (2021)

Comparison of the airway microbiota in children with chronic suppurative lung disease
por: Ahmed, Bushra, et al.
Publicado: (2021)

Caregivers’ and healthcare professionals’ perspective of barriers and facilitators to health service access for asthmatic children: a qualitative study
por: Ardura-Garcia, Cristina, et al.
Publicado: (2021)

Routine lung volume recruitment in boys with Duchenne muscular dystrophy: a randomised clinical trial
por: Katz, Sherri L, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_h10qcl75kp8ckj0o131cc8n5n7