Cargando…

The role of mTOR pathway as target for treatment in adrenocortical cancer

Adrenocortical carcinomas (ACCs) are rare tumors with scant treatment options for which new treatments are required. The mTOR pathway mediates the intracellular signals of several growth factors, including the insulin-like growth factors (IGFs), and therefore represents a potential attractive pathwa...

Descripción completa

Detalles Bibliográficos
Autores principales:	De Martino, Maria Cristina, Feelders, Richard A, Pivonello, Claudia, Simeoli, Chiara, Papa, Fortuna, Colao, Annamaria, Pivonello, Rosario, Hofland, Leo J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Bioscientifica Ltd 2019
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6733361/ https://www.ncbi.nlm.nih.gov/pubmed/31398711 http://dx.doi.org/10.1530/EC-19-0224

Ejemplares similares

IGF and mTOR pathway expression and in vitro effects of linsitinib and mTOR inhibitors in adrenocortical cancer
por: De Martino, Maria Cristina, et al.
Publicado: (2019)

The dual targeting of insulin and insulin-like growth factor 1 receptor enhances the mTOR inhibitor-mediated antitumor efficacy in hepatocellular carcinoma
por: Pivonello, Claudia, et al.
Publicado: (2016)

Vitamin D reverts resistance to the mTOR inhibitor everolimus in hepatocellular carcinoma through the activation of a miR-375/oncogenes circuit
por: Provvisiero, Donatella Paola, et al.
Publicado: (2019)

Vitamin D Reverts the Exosome-Mediated Transfer of Cancer Resistance to the mTOR Inhibitor Everolimus in Hepatocellular Carcinoma
por: Negri, Mariarosaria, et al.
Publicado: (2022)

MicroRNAs and Long Non-Coding RNAs in Adrenocortical Carcinoma
por: Detomas, Mario, et al.
Publicado: (2022)

Cushing’s disease: adrenal steroidogenesis inhibitors
por: Pivonello, Rosario, et al.
Publicado: (2022)

Influence of Bisphenol A on Type 2 Diabetes Mellitus
por: Provvisiero, Donatella Paola, et al.
Publicado: (2016)

SUN-358 Dual Release Hydrocortisone as a New Treatment for Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency
por: Simeoli, Chiara, et al.
Publicado: (2019)

Medical Treatment of Cushing's Disease: An Overview of the Current and Recent Clinical Trials
por: Pivonello, Rosario, et al.
Publicado: (2020)

Neuropsychiatric disorders in Cushing's syndrome
por: Pivonello, Rosario, et al.
Publicado: (2015)

The dopaminergic control of Cushing’s syndrome
por: Pivonello, R., et al.
Publicado: (2022)

The GH-IGF-SST system in hepatocellular carcinoma: biological and molecular pathogenetic mechanisms and therapeutic targets
por: Pivonello, Claudia, et al.
Publicado: (2014)

Approach to the Patient With Prolactinoma
por: Auriemma, Renata S, et al.
Publicado: (2023)

Severe impact of late diagnosis of congenital adrenal hyperplasia on gender identity, sexual orientation and function: case report and review of the literature
por: Simeoli, Chiara, et al.
Publicado: (2022)

The effects of somatostatin analogue therapy on pituitary tumor volume in patients with acromegaly
por: Colao, Annamaria, et al.
Publicado: (2015)

The treatment with pasireotide in Cushing’s disease: effect of long-term treatment on clinical picture and metabolic profile and management of adverse events in the experience of a single center
por: Simeoli, C., et al.
Publicado: (2019)

Vitamin D-Induced Molecular Mechanisms to Potentiate Cancer Therapy and to Reverse Drug-Resistance in Cancer Cells
por: Negri, Mariarosaria, et al.
Publicado: (2020)

Resistance to Dopamine Agonists in Pituitary Tumors: Molecular Mechanisms
por: Pivonello, Claudia, et al.
Publicado: (2022)

Testis-Specific Genes Deregulation in the Testis of COVID-19 Patients: A Potential Driver of Spermatogenesis Disruption?
por: Pivonello, Rosario, et al.
Publicado: (2022)

Imbalanced cortisol concentrations in glycogen storage disease type I: evidence for a possible link between endocrine regulation and metabolic derangement
por: Rossi, Alessandro, et al.
Publicado: (2020)

Metabolic effects of prolactin
por: Pirchio, Rosa, et al.
Publicado: (2022)

The role of melatonin in the molecular mechanisms underlying metaflammation and infections in obesity: A narrative review
por: Pivonello, Claudia, et al.
Publicado: (2021)

Interpreting biochemical control response rates with first-generation somatostatin analogues in acromegaly
por: Colao, Annamaria, et al.
Publicado: (2015)

Glucose Abnormalities Associated to Prolactin Secreting Pituitary Adenomas
por: Auriemma, Renata S., et al.
Publicado: (2019)

Effects of Pituitary Surgery and High-Dose Cabergoline Therapy on Metabolic Profile in Patients With Prolactinoma Resistant to Conventional Cabergoline Treatment
por: Pirchio, Rosa, et al.
Publicado: (2021)

Smoke, alcohol and drug addiction and female fertility
por: de Angelis, Cristina, et al.
Publicado: (2020)

Isoform-specific NF1 mRNA levels correlate with disease severity in Neurofibromatosis type 1
por: Assunto, Antonia, et al.
Publicado: (2019)

Metabolic Disorders and Male Hypogonadotropic Hypogonadism
por: Pivonello, Rosario, et al.
Publicado: (2019)

Bisphenol A: an emerging threat to female fertility
por: Pivonello, Claudia, et al.
Publicado: (2020)

mTOR Pathway and mTOR Inhibitors in Head and Neck Cancer
por: Gao, Wei, et al.
Publicado: (2012)

Serum IGF-1 is associated with cognitive functions in early, drug-naïve Parkinson’s disease
por: Picillo, Marina, et al.
Publicado: (2017)

The Interplay Between Prolactin and Reproductive System: Focus on Uterine Pathophysiology
por: Auriemma, Renata S., et al.
Publicado: (2020)

How to Differentiate Benign from Malignant Adrenocortical Tumors?
por: Viëtor, Charlotte L., et al.
Publicado: (2021)

IDO1 involvement in mTOR pathway: a molecular mechanism of resistance to mTOR targeting in medulloblastoma
por: Folgiero, Valentina, et al.
Publicado: (2016)

mTOR signaling pathway and mTOR inhibitors in cancer: progress and challenges
por: Zou, Zhilin, et al.
Publicado: (2020)

Long-term high-dose l-arginine supplementation in patients with vasculogenic erectile dysfunction: a multicentre, double-blind, randomized, placebo-controlled clinical trial
por: Menafra, D., et al.
Publicado: (2022)

COVID-19 and Cushing's syndrome: recommendations for a special population with endogenous glucocorticoid excess
por: Pivonello, Rosario, et al.
Publicado: (2020)

Glucocorticoid Receptor Antagonism Upregulates Somatostatin Receptor Subtype 2 Expression in ACTH-Producing Neuroendocrine Tumors: New Insight Based on the Selective Glucocorticoid Receptor Modulator Relacorilant
por: Pivonello, Rosario, et al.
Publicado: (2022)

The Efficacy of Mitotane in Human Primary Adrenocortical Carcinoma Cultures
por: van Koetsveld, Peter M, et al.
Publicado: (2019)

mTOR Pathways in Cancer and Autophagy
por: Paquette, Mathieu, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_2eg4pdajg5q2i4ojolbqu7lg48