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Residual stenosis after carotid artery stenting: Effect on periprocedural and long-term outcomes

OBJECTIVE: This study investigated the effect of residual stenosis after carotid artery stenting (CAS) on periprocedural and long-term outcomes. METHODS: Patients treated with CAS for symptomatic or asymptomatic carotid arterial stenosis were consecutively enrolled. Residual stenosis was estimated f...

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Detalles Bibliográficos
Autores principales: Kang, Jihoon, Hong, Jeong-Ho, Kim, Beom Joon, Bae, Hee-Joon, Kwon, O-Ki, Oh, Chang Wan, Jung, Cheolkyu, Lee, Ji Sung, Han, Moon-Ku
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6733450/
https://www.ncbi.nlm.nih.gov/pubmed/31498785
http://dx.doi.org/10.1371/journal.pone.0216592
Descripción
Sumario:OBJECTIVE: This study investigated the effect of residual stenosis after carotid artery stenting (CAS) on periprocedural and long-term outcomes. METHODS: Patients treated with CAS for symptomatic or asymptomatic carotid arterial stenosis were consecutively enrolled. Residual stenosis was estimated from post-procedure angiography findings. The effects of residual stenosis on 30-day periprocedural outcome and times to restenosis and clinical outcome were analyzed using logistic regression models and Wei-Lin-Weissfeld models, respectively. RESULTS: A total of 412 patients (age, 64.7 ± 17.0 years; male, 82.0%) were enrolled. The median baseline stenosis was 80% (interquartile range [IQR], 70–90%), which improved to 10% (0–30%) for residual stenosis. Residual stenosis was significantly associated with periprocedural outcome (adjusted odds ratio, 0.983; 95% confidence interval [CI], 0.965–0.999, P = 0.01) after adjustment for baseline stenosis, age, hypertension, symptomaticity, and statin use. Over the 5-year observation period, residual stenosis did not increase the global hazard for restenosis and clinical outcome (adjusted hazard ratio, 1.011; 95% CI, 0.997–1.025. In the event-specific model, residual stenosis increased the hazard for restenosis (adjusted hazard ratio, 1.041; 1.012–1.072) but not for clinical outcome (adjusted hazard ratio, 1.011; 0.997–1.025). CONCLUSIONS: Residual stenosis after carotid artery stenting may be useful to predict periprocedural outcome and restenosis.