G-protein-coupled receptor 40 agonist GW9508 potentiates glucose-stimulated insulin secretion through activation of protein kinase Cα and ε in INS-1 cells

OBJECTIVE: The mechanism by which G-protein-coupled receptor 40 (GPR40) signaling amplifies glucose-stimulated insulin secretion through activation of protein kinase C (PKC) is unknown. We examined whether a GPR40 agonist, GW9508, could stimulate conventional and novel isoforms of PKC at two glucose...

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Detalles Bibliográficos
Autores principales: Hashimoto, Takuya, Mogami, Hideo, Tsuriya, Daisuke, Morita, Hiroshi, Sasaki, Shigekazu, Kumada, Tatsuro, Suzuki, Yuko, Urano, Tetsumei, Oki, Yutaka, Suda, Takafumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6733457/
https://www.ncbi.nlm.nih.gov/pubmed/31498851
http://dx.doi.org/10.1371/journal.pone.0222179

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