De Novo Design of Bioactive Protein Switches

Allosteric regulation of protein function is widespread in biology, but challenging for de novo protein design as it requires explicit design of multiple states with comparable free energies. We explore the possibility of de novo designing switchable protein systems through modulation of competing i...

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Detalles Bibliográficos
Autores principales: Langan, Robert A., Boyken, Scott E., Ng, Andrew H., Samson, Jennifer A., Dods, Galen, Westbrook, Alexandra M., Nguyen, Taylor H., Lajoie, Marc J., Chen, Zibo, Berger, Stephanie, Mulligan, Vikram Khipple, Dueber, John E., Novak, Walter R.P., El-Samad, Hana, Baker, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6733528/
https://www.ncbi.nlm.nih.gov/pubmed/31341284
http://dx.doi.org/10.1038/s41586-019-1432-8

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