Effect of vaporized perfluorocarbon on oxidative stress during the cold ischemia phase of lung graft preservation

Liquid perfluorocarbon (PFC) instillation has been studied experimentally as an adjuvant therapy in the preservation of lung grafts during cold ischemia. The objective of this study was to evaluate whether vaporized PFC is also protective of lung grafts at different cold ischemia times. We performed...

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Detalles Bibliográficos
Autores principales: Ferrari, Renata Salatti, Thomaz, Leonardo Dalla Giacomassa Rocha, Simoneti, Lucas Elias Lise, Ulbrich, Jane Maria, Andrade, Cristiano Feijó
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Pneumologia e Tisiologia 2019
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6733723/
https://www.ncbi.nlm.nih.gov/pubmed/30942284
http://dx.doi.org/10.1590/1806-3713/e20170288
Descripción
Sumario:Liquid perfluorocarbon (PFC) instillation has been studied experimentally as an adjuvant therapy in the preservation of lung grafts during cold ischemia. The objective of this study was to evaluate whether vaporized PFC is also protective of lung grafts at different cold ischemia times. We performed histological analysis of and measured oxidative stress in the lungs of animals that received only preservation solution with low-potassium dextran (LPD) or vaporized PFC together with LPD. We conclude that vaporized PFC reduces the production of free radicals and the number of pulmonary structural changes resulting from cold ischemia.

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