Effect of vaporized perfluorocarbon on oxidative stress during the cold ischemia phase of lung graft preservation

Liquid perfluorocarbon (PFC) instillation has been studied experimentally as an adjuvant therapy in the preservation of lung grafts during cold ischemia. The objective of this study was to evaluate whether vaporized PFC is also protective of lung grafts at different cold ischemia times. We performed...

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Autores principales: Ferrari, Renata Salatti, Thomaz, Leonardo Dalla Giacomassa Rocha, Simoneti, Lucas Elias Lise, Ulbrich, Jane Maria, Andrade, Cristiano Feijó
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Pneumologia e Tisiologia 2019
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6733723/
https://www.ncbi.nlm.nih.gov/pubmed/30942284
http://dx.doi.org/10.1590/1806-3713/e20170288
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author Ferrari, Renata Salatti
Thomaz, Leonardo Dalla Giacomassa Rocha
Simoneti, Lucas Elias Lise
Ulbrich, Jane Maria
Andrade, Cristiano Feijó
author_facet Ferrari, Renata Salatti
Thomaz, Leonardo Dalla Giacomassa Rocha
Simoneti, Lucas Elias Lise
Ulbrich, Jane Maria
Andrade, Cristiano Feijó
author_sort Ferrari, Renata Salatti
collection PubMed
description Liquid perfluorocarbon (PFC) instillation has been studied experimentally as an adjuvant therapy in the preservation of lung grafts during cold ischemia. The objective of this study was to evaluate whether vaporized PFC is also protective of lung grafts at different cold ischemia times. We performed histological analysis of and measured oxidative stress in the lungs of animals that received only preservation solution with low-potassium dextran (LPD) or vaporized PFC together with LPD. We conclude that vaporized PFC reduces the production of free radicals and the number of pulmonary structural changes resulting from cold ischemia.
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spelling pubmed-67337232019-10-03 Effect of vaporized perfluorocarbon on oxidative stress during the cold ischemia phase of lung graft preservation Ferrari, Renata Salatti Thomaz, Leonardo Dalla Giacomassa Rocha Simoneti, Lucas Elias Lise Ulbrich, Jane Maria Andrade, Cristiano Feijó J Bras Pneumol Brief Communication Liquid perfluorocarbon (PFC) instillation has been studied experimentally as an adjuvant therapy in the preservation of lung grafts during cold ischemia. The objective of this study was to evaluate whether vaporized PFC is also protective of lung grafts at different cold ischemia times. We performed histological analysis of and measured oxidative stress in the lungs of animals that received only preservation solution with low-potassium dextran (LPD) or vaporized PFC together with LPD. We conclude that vaporized PFC reduces the production of free radicals and the number of pulmonary structural changes resulting from cold ischemia. Sociedade Brasileira de Pneumologia e Tisiologia 2019 /pmc/articles/PMC6733723/ /pubmed/30942284 http://dx.doi.org/10.1590/1806-3713/e20170288 Text en © 2019 Sociedade Brasileira de Pneumologia e Tisiologia https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License
spellingShingle Brief Communication
Ferrari, Renata Salatti
Thomaz, Leonardo Dalla Giacomassa Rocha
Simoneti, Lucas Elias Lise
Ulbrich, Jane Maria
Andrade, Cristiano Feijó
Effect of vaporized perfluorocarbon on oxidative stress during the cold ischemia phase of lung graft preservation
title Effect of vaporized perfluorocarbon on oxidative stress during the cold ischemia phase of lung graft preservation
title_full Effect of vaporized perfluorocarbon on oxidative stress during the cold ischemia phase of lung graft preservation
title_fullStr Effect of vaporized perfluorocarbon on oxidative stress during the cold ischemia phase of lung graft preservation
title_full_unstemmed Effect of vaporized perfluorocarbon on oxidative stress during the cold ischemia phase of lung graft preservation
title_short Effect of vaporized perfluorocarbon on oxidative stress during the cold ischemia phase of lung graft preservation
title_sort effect of vaporized perfluorocarbon on oxidative stress during the cold ischemia phase of lung graft preservation
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6733723/
https://www.ncbi.nlm.nih.gov/pubmed/30942284
http://dx.doi.org/10.1590/1806-3713/e20170288
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