Cargando…

Pulmonary nontuberculous mycobacterial infections: presumptive diagnosis based on the international microbiological criteria adopted in the state of São Paulo, Brazil, 2011-2014

OBJECTIVE: Pulmonary nontuberculous mycobacterial infections are caused by nontuberculous mycobacteria (NTM), the microbiological diagnosis of which involves the isolation and identification of the same species in at least two sputum samples, one BAL fluid sample, or one lung biopsy sample. The obje...

Descripción completa

Detalles Bibliográficos
Autores principales: Marques, Lilian Regina Macelloni, Ferrazoli, Lucilaine, Chimara, Érica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Pneumologia e Tisiologia 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6733752/
https://www.ncbi.nlm.nih.gov/pubmed/31038648
http://dx.doi.org/10.1590/1806-3713/e20180278
_version_ 1783450019280453632
author Marques, Lilian Regina Macelloni
Ferrazoli, Lucilaine
Chimara, Érica
author_facet Marques, Lilian Regina Macelloni
Ferrazoli, Lucilaine
Chimara, Érica
author_sort Marques, Lilian Regina Macelloni
collection PubMed
description OBJECTIVE: Pulmonary nontuberculous mycobacterial infections are caused by nontuberculous mycobacteria (NTM), the microbiological diagnosis of which involves the isolation and identification of the same species in at least two sputum samples, one BAL fluid sample, or one lung biopsy sample. The objective of the present study was to determine the frequency at which the various NTM species are identified among selected individuals and in potential cases of pulmonary nontuberculous mycobacterial infection. METHODS: This was a retrospective analysis of the data on species isolated from respiratory specimens collected from 2,843 individuals between 2011 and 2014. Potential NTM infection cases were identified on the basis of the international microbiological criteria adopted in the state of São Paulo. RESULTS: A total of 50 species were identified using the molecular method PCR-restriction enzyme analysis. Samples collected from 1,014 individuals were analyzed in relation to the microbiological criteria, and 448 (44.18%) had a presumptive diagnosis of pulmonary nontuberculous mycobacterial infection, the species identified most frequently being, in descending order, Mycobacterium kansasii, M. abscessus, M. intracellulare, M. avium, and M. szulgai. CONCLUSIONS: Although various NTM species were identified among the individuals studied, those presumptively identified most frequently on the basis of the microbiological criteria adopted in the state of São Paulo were the ones that are most commonly associated with pulmonary nontuberculous mycobacterial infection worldwide or in specific geographic regions.
format Online
Article
Text
id pubmed-6733752
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Sociedade Brasileira de Pneumologia e Tisiologia
record_format MEDLINE/PubMed
spelling pubmed-67337522019-10-02 Pulmonary nontuberculous mycobacterial infections: presumptive diagnosis based on the international microbiological criteria adopted in the state of São Paulo, Brazil, 2011-2014 Marques, Lilian Regina Macelloni Ferrazoli, Lucilaine Chimara, Érica J Bras Pneumol Original Article OBJECTIVE: Pulmonary nontuberculous mycobacterial infections are caused by nontuberculous mycobacteria (NTM), the microbiological diagnosis of which involves the isolation and identification of the same species in at least two sputum samples, one BAL fluid sample, or one lung biopsy sample. The objective of the present study was to determine the frequency at which the various NTM species are identified among selected individuals and in potential cases of pulmonary nontuberculous mycobacterial infection. METHODS: This was a retrospective analysis of the data on species isolated from respiratory specimens collected from 2,843 individuals between 2011 and 2014. Potential NTM infection cases were identified on the basis of the international microbiological criteria adopted in the state of São Paulo. RESULTS: A total of 50 species were identified using the molecular method PCR-restriction enzyme analysis. Samples collected from 1,014 individuals were analyzed in relation to the microbiological criteria, and 448 (44.18%) had a presumptive diagnosis of pulmonary nontuberculous mycobacterial infection, the species identified most frequently being, in descending order, Mycobacterium kansasii, M. abscessus, M. intracellulare, M. avium, and M. szulgai. CONCLUSIONS: Although various NTM species were identified among the individuals studied, those presumptively identified most frequently on the basis of the microbiological criteria adopted in the state of São Paulo were the ones that are most commonly associated with pulmonary nontuberculous mycobacterial infection worldwide or in specific geographic regions. Sociedade Brasileira de Pneumologia e Tisiologia 2019 /pmc/articles/PMC6733752/ /pubmed/31038648 http://dx.doi.org/10.1590/1806-3713/e20180278 Text en © 2019 Sociedade Brasileira de Pneumologia e Tisiologia https://creativecommons.org/licenses/by-nc/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License
spellingShingle Original Article
Marques, Lilian Regina Macelloni
Ferrazoli, Lucilaine
Chimara, Érica
Pulmonary nontuberculous mycobacterial infections: presumptive diagnosis based on the international microbiological criteria adopted in the state of São Paulo, Brazil, 2011-2014
title Pulmonary nontuberculous mycobacterial infections: presumptive diagnosis based on the international microbiological criteria adopted in the state of São Paulo, Brazil, 2011-2014
title_full Pulmonary nontuberculous mycobacterial infections: presumptive diagnosis based on the international microbiological criteria adopted in the state of São Paulo, Brazil, 2011-2014
title_fullStr Pulmonary nontuberculous mycobacterial infections: presumptive diagnosis based on the international microbiological criteria adopted in the state of São Paulo, Brazil, 2011-2014
title_full_unstemmed Pulmonary nontuberculous mycobacterial infections: presumptive diagnosis based on the international microbiological criteria adopted in the state of São Paulo, Brazil, 2011-2014
title_short Pulmonary nontuberculous mycobacterial infections: presumptive diagnosis based on the international microbiological criteria adopted in the state of São Paulo, Brazil, 2011-2014
title_sort pulmonary nontuberculous mycobacterial infections: presumptive diagnosis based on the international microbiological criteria adopted in the state of são paulo, brazil, 2011-2014
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6733752/
https://www.ncbi.nlm.nih.gov/pubmed/31038648
http://dx.doi.org/10.1590/1806-3713/e20180278
work_keys_str_mv AT marqueslilianreginamacelloni pulmonarynontuberculousmycobacterialinfectionspresumptivediagnosisbasedontheinternationalmicrobiologicalcriteriaadoptedinthestateofsaopaulobrazil20112014
AT ferrazolilucilaine pulmonarynontuberculousmycobacterialinfectionspresumptivediagnosisbasedontheinternationalmicrobiologicalcriteriaadoptedinthestateofsaopaulobrazil20112014
AT chimaraerica pulmonarynontuberculousmycobacterialinfectionspresumptivediagnosisbasedontheinternationalmicrobiologicalcriteriaadoptedinthestateofsaopaulobrazil20112014