Optimization of the extraction condition for benzyl isothiocyanate contents in Salvadora persica roots “Siwak”

Benzyl isothocyanate is the major active antibacterial metabolite in Salvadora persica roots “Siwak” beside two minor isothiocyanate derivatives namely; 3-methoxy benzyl isothiocyanate and 3-hydroxy benzyl isothiocyanate. The extraction condition effect on the amount of benzyl isothiocyanate was exp...

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Autores principales: Abdel-Kader, Maged S., Alam, Prawez, Kamal, Y.T., Alkharfy, Khalid M., Foudah, Ahmed I., Alqasoumi, Saleh I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6733780/
https://www.ncbi.nlm.nih.gov/pubmed/31516317
http://dx.doi.org/10.1016/j.jsps.2019.04.011
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author Abdel-Kader, Maged S.
Alam, Prawez
Kamal, Y.T.
Alkharfy, Khalid M.
Foudah, Ahmed I.
Alqasoumi, Saleh I.
author_facet Abdel-Kader, Maged S.
Alam, Prawez
Kamal, Y.T.
Alkharfy, Khalid M.
Foudah, Ahmed I.
Alqasoumi, Saleh I.
author_sort Abdel-Kader, Maged S.
collection PubMed
description Benzyl isothocyanate is the major active antibacterial metabolite in Salvadora persica roots “Siwak” beside two minor isothiocyanate derivatives namely; 3-methoxy benzyl isothiocyanate and 3-hydroxy benzyl isothiocyanate. The extraction condition effect on the amount of benzyl isothiocyanate was explored in detailed study. Both cold and hot extraction with different solvents was applied. The amount of benzyl isothiocyanate was estimated using HPLC and HPTLC. The results indicated that cold extraction of the fresh samples with chloroform offers the maximum amount of benzyl isothiocyanate. Drying process leads to great loss of the active component of Siwak.
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spelling pubmed-67337802019-09-12 Optimization of the extraction condition for benzyl isothiocyanate contents in Salvadora persica roots “Siwak” Abdel-Kader, Maged S. Alam, Prawez Kamal, Y.T. Alkharfy, Khalid M. Foudah, Ahmed I. Alqasoumi, Saleh I. Saudi Pharm J Article Benzyl isothocyanate is the major active antibacterial metabolite in Salvadora persica roots “Siwak” beside two minor isothiocyanate derivatives namely; 3-methoxy benzyl isothiocyanate and 3-hydroxy benzyl isothiocyanate. The extraction condition effect on the amount of benzyl isothiocyanate was explored in detailed study. Both cold and hot extraction with different solvents was applied. The amount of benzyl isothiocyanate was estimated using HPLC and HPTLC. The results indicated that cold extraction of the fresh samples with chloroform offers the maximum amount of benzyl isothiocyanate. Drying process leads to great loss of the active component of Siwak. Elsevier 2019-09 2019-04-20 /pmc/articles/PMC6733780/ /pubmed/31516317 http://dx.doi.org/10.1016/j.jsps.2019.04.011 Text en © 2019 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Abdel-Kader, Maged S.
Alam, Prawez
Kamal, Y.T.
Alkharfy, Khalid M.
Foudah, Ahmed I.
Alqasoumi, Saleh I.
Optimization of the extraction condition for benzyl isothiocyanate contents in Salvadora persica roots “Siwak”
title Optimization of the extraction condition for benzyl isothiocyanate contents in Salvadora persica roots “Siwak”
title_full Optimization of the extraction condition for benzyl isothiocyanate contents in Salvadora persica roots “Siwak”
title_fullStr Optimization of the extraction condition for benzyl isothiocyanate contents in Salvadora persica roots “Siwak”
title_full_unstemmed Optimization of the extraction condition for benzyl isothiocyanate contents in Salvadora persica roots “Siwak”
title_short Optimization of the extraction condition for benzyl isothiocyanate contents in Salvadora persica roots “Siwak”
title_sort optimization of the extraction condition for benzyl isothiocyanate contents in salvadora persica roots “siwak”
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6733780/
https://www.ncbi.nlm.nih.gov/pubmed/31516317
http://dx.doi.org/10.1016/j.jsps.2019.04.011
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