Cargando…

What Have Slow Progressors Taught Us About T1D—Mind the Gap!

PURPOSE OF REVIEW: Progression rate from islet autoimmunity to clinical diabetes is unpredictable. In this review, we focus on an intriguing group of slow progressors who have high-risk islet autoantibody profiles but some remain diabetes free for decades. RECENT FINDINGS: Birth cohort studies show...

Descripción completa

Detalles Bibliográficos
Autores principales: Gillespie, Kathleen M., Long, Anna E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6733826/
https://www.ncbi.nlm.nih.gov/pubmed/31501992
http://dx.doi.org/10.1007/s11892-019-1219-1
_version_ 1783450032772481024
author Gillespie, Kathleen M.
Long, Anna E.
author_facet Gillespie, Kathleen M.
Long, Anna E.
author_sort Gillespie, Kathleen M.
collection PubMed
description PURPOSE OF REVIEW: Progression rate from islet autoimmunity to clinical diabetes is unpredictable. In this review, we focus on an intriguing group of slow progressors who have high-risk islet autoantibody profiles but some remain diabetes free for decades. RECENT FINDINGS: Birth cohort studies show that islet autoimmunity presents early in life and approximately 70% of individuals with multiple islet autoantibodies develop clinical symptoms of diabetes within 10 years. Some “at risk” individuals however progress very slowly. Recent genetic studies confirm that approximately half of type 1 diabetes (T1D) is diagnosed in adulthood. This creates a conundrum; slow progressors cannot account for the number of cases diagnosed in the adult population. SUMMARY: There is a large “gap” in our understanding of the pathogenesis of adult onset T1D and a need for longitudinal studies to determine whether there are “at risk” adults in the general population; some of whom are rapid and some slow adult progressors.
format Online
Article
Text
id pubmed-6733826
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Springer US
record_format MEDLINE/PubMed
spelling pubmed-67338262019-09-23 What Have Slow Progressors Taught Us About T1D—Mind the Gap! Gillespie, Kathleen M. Long, Anna E. Curr Diab Rep Pathogenesis of Type 1 Diabetes (A Pugliese and SJ Richardson, Section Editors) PURPOSE OF REVIEW: Progression rate from islet autoimmunity to clinical diabetes is unpredictable. In this review, we focus on an intriguing group of slow progressors who have high-risk islet autoantibody profiles but some remain diabetes free for decades. RECENT FINDINGS: Birth cohort studies show that islet autoimmunity presents early in life and approximately 70% of individuals with multiple islet autoantibodies develop clinical symptoms of diabetes within 10 years. Some “at risk” individuals however progress very slowly. Recent genetic studies confirm that approximately half of type 1 diabetes (T1D) is diagnosed in adulthood. This creates a conundrum; slow progressors cannot account for the number of cases diagnosed in the adult population. SUMMARY: There is a large “gap” in our understanding of the pathogenesis of adult onset T1D and a need for longitudinal studies to determine whether there are “at risk” adults in the general population; some of whom are rapid and some slow adult progressors. Springer US 2019-09-10 2019 /pmc/articles/PMC6733826/ /pubmed/31501992 http://dx.doi.org/10.1007/s11892-019-1219-1 Text en © The Author(s) 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Pathogenesis of Type 1 Diabetes (A Pugliese and SJ Richardson, Section Editors)
Gillespie, Kathleen M.
Long, Anna E.
What Have Slow Progressors Taught Us About T1D—Mind the Gap!
title What Have Slow Progressors Taught Us About T1D—Mind the Gap!
title_full What Have Slow Progressors Taught Us About T1D—Mind the Gap!
title_fullStr What Have Slow Progressors Taught Us About T1D—Mind the Gap!
title_full_unstemmed What Have Slow Progressors Taught Us About T1D—Mind the Gap!
title_short What Have Slow Progressors Taught Us About T1D—Mind the Gap!
title_sort what have slow progressors taught us about t1d—mind the gap!
topic Pathogenesis of Type 1 Diabetes (A Pugliese and SJ Richardson, Section Editors)
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6733826/
https://www.ncbi.nlm.nih.gov/pubmed/31501992
http://dx.doi.org/10.1007/s11892-019-1219-1
work_keys_str_mv AT gillespiekathleenm whathaveslowprogressorstaughtusaboutt1dmindthegap
AT longannae whathaveslowprogressorstaughtusaboutt1dmindthegap