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p97 regulates GluA1 homomeric AMPA receptor formation and plasma membrane expression
The α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid subtype glutamate receptors (AMPARs) mediate the fast excitatory synaptic transmission in the mammalian brain and are important for synaptic plasticity. In particular, the rapid insertion of the GluA1 homomeric (GluA1-homo) AMPARs into the pos...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6733861/ https://www.ncbi.nlm.nih.gov/pubmed/31501443 http://dx.doi.org/10.1038/s41467-019-12096-7 |
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author | Ge, Yuan Tian, Meng Liu, Lidong Wong, Tak Pan Gong, Bo Wu, Dongchuan Cho, Taesup Lin, Shujun Kast, Jürgen Lu, Jie Wang, Yu Tian |
author_facet | Ge, Yuan Tian, Meng Liu, Lidong Wong, Tak Pan Gong, Bo Wu, Dongchuan Cho, Taesup Lin, Shujun Kast, Jürgen Lu, Jie Wang, Yu Tian |
author_sort | Ge, Yuan |
collection | PubMed |
description | The α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid subtype glutamate receptors (AMPARs) mediate the fast excitatory synaptic transmission in the mammalian brain and are important for synaptic plasticity. In particular, the rapid insertion of the GluA1 homomeric (GluA1-homo) AMPARs into the postsynaptic membrane is considered to be critical in the expression of hippocampal CA1 long-term potentiation (LTP), which is important for certain forms of learning and memory. However, how the formation and trafficking of GluA1-homo AMPARs are regulated remains poorly understood. Here, we report that p97 specifically interacts with and promotes the formation of GluA1-homo AMPARs. The association with p97 retains GluA1-homo AMPARs in the intracellular compartment under basal conditions, and its dissociation allows GluA1-homo AMPARs to be rapidly inserted into the postsynaptic membrane shortly after LTP induction. Thus, our results shed lights into the molecular mechanisms by which p97 regulates GluA1-homo AMPARs formation and trafficking, thereby playing a critical role in mediating synaptic plasticity. |
format | Online Article Text |
id | pubmed-6733861 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-67338612019-09-11 p97 regulates GluA1 homomeric AMPA receptor formation and plasma membrane expression Ge, Yuan Tian, Meng Liu, Lidong Wong, Tak Pan Gong, Bo Wu, Dongchuan Cho, Taesup Lin, Shujun Kast, Jürgen Lu, Jie Wang, Yu Tian Nat Commun Article The α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid subtype glutamate receptors (AMPARs) mediate the fast excitatory synaptic transmission in the mammalian brain and are important for synaptic plasticity. In particular, the rapid insertion of the GluA1 homomeric (GluA1-homo) AMPARs into the postsynaptic membrane is considered to be critical in the expression of hippocampal CA1 long-term potentiation (LTP), which is important for certain forms of learning and memory. However, how the formation and trafficking of GluA1-homo AMPARs are regulated remains poorly understood. Here, we report that p97 specifically interacts with and promotes the formation of GluA1-homo AMPARs. The association with p97 retains GluA1-homo AMPARs in the intracellular compartment under basal conditions, and its dissociation allows GluA1-homo AMPARs to be rapidly inserted into the postsynaptic membrane shortly after LTP induction. Thus, our results shed lights into the molecular mechanisms by which p97 regulates GluA1-homo AMPARs formation and trafficking, thereby playing a critical role in mediating synaptic plasticity. Nature Publishing Group UK 2019-09-09 /pmc/articles/PMC6733861/ /pubmed/31501443 http://dx.doi.org/10.1038/s41467-019-12096-7 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Ge, Yuan Tian, Meng Liu, Lidong Wong, Tak Pan Gong, Bo Wu, Dongchuan Cho, Taesup Lin, Shujun Kast, Jürgen Lu, Jie Wang, Yu Tian p97 regulates GluA1 homomeric AMPA receptor formation and plasma membrane expression |
title | p97 regulates GluA1 homomeric AMPA receptor formation and plasma membrane expression |
title_full | p97 regulates GluA1 homomeric AMPA receptor formation and plasma membrane expression |
title_fullStr | p97 regulates GluA1 homomeric AMPA receptor formation and plasma membrane expression |
title_full_unstemmed | p97 regulates GluA1 homomeric AMPA receptor formation and plasma membrane expression |
title_short | p97 regulates GluA1 homomeric AMPA receptor formation and plasma membrane expression |
title_sort | p97 regulates glua1 homomeric ampa receptor formation and plasma membrane expression |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6733861/ https://www.ncbi.nlm.nih.gov/pubmed/31501443 http://dx.doi.org/10.1038/s41467-019-12096-7 |
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