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Na(V)1.2 haploinsufficiency in Scn2a knock-out mice causes an autistic-like phenotype attenuated with age
Mutations of the SCN2A gene, encoding the voltage gated sodium channel Na(V)1.2, have been associated to a wide spectrum of epileptic disorders ranging from benign familial neonatal-infantile seizures to early onset epileptic encephalopathies such as Ohtahara syndrome. These phenotypes may be caused...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6733925/ https://www.ncbi.nlm.nih.gov/pubmed/31501495 http://dx.doi.org/10.1038/s41598-019-49392-7 |