Human multipotent hematopoietic progenitor cell expansion is neither supported in endothelial and endothelial/mesenchymal co-cultures nor in NSG mice

Endothelial and mesenchymal stromal cells (ECs/MSCs) are crucial components of hematopoietic bone marrow stem cell niches. Both cell types appear to be required to support the maintenance and expansion of multipotent hematopoietic cells, i.e. hematopoietic stem cells (HSCs) and multipotent progenito...

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Detalles Bibliográficos
Autores principales: Radtke, Stefan, Görgens, André, da Conceição Castro, Symone Vitoriano, Kordelas, Lambros, Köninger, Angela, Dürig, Jan, Möllmann, Michael, Horn, Peter A., Giebel, Bernd
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6733927/
https://www.ncbi.nlm.nih.gov/pubmed/31501490
http://dx.doi.org/10.1038/s41598-019-49221-x

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