TRAF3 regulates the oncogenic proteins Pim2 and c-Myc to restrain survival in normal and malignant B cells

TRAF3 is a versatile intracellular adapter protein with multiple context-specific roles. Uniquely in B cells, TRAF3 deficiency enhances survival and increases the risk of transformation, as loss of TRAF3 is observed in several types of B cell cancers. Here, we report a new mechanism for TRAF3 in the...

Descripción completa

Detalles Bibliográficos
Autores principales: Whillock, Amy L., Mambetsariev, Nurbek, Lin, Wai W., Stunz, Laura L., Bishop, Gail A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6733949/
https://www.ncbi.nlm.nih.gov/pubmed/31501481
http://dx.doi.org/10.1038/s41598-019-49390-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6733949/
https://www.ncbi.nlm.nih.gov/pubmed/31501481
http://dx.doi.org/10.1038/s41598-019-49390-9

Ejemplares similares