Effects of two isometheptene enantiomers in isolated human blood vessels and rat middle meningeal artery – potential antimigraine efficacy

BACKGROUND: Racemic isometheptene [(RS)-isometheptene] is an antimigraine drug that due to its cardiovascular side-effects was separated into its enantiomers, (R)- and (S)-isometheptene. This study set out to characterize the contribution of each enantiomer to its vasoactive profile. Moreover, rat n...

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Detalles Bibliográficos
Autores principales: Labastida-Ramírez, Alejandro, Rubio-Beltrán, Eloísa, Haanes, Kristian A., de Vries, René, Dammers, Ruben, Bogers, A. J. J. C., van den Bogaerdt, Antoon, Daugherty, Bruce L., Danser, Alexander H. J., Villalón, Carlos M., MaassenVanDenBrink, Antoinette
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Milan 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6734216/
https://www.ncbi.nlm.nih.gov/pubmed/31053059
http://dx.doi.org/10.1186/s10194-019-1003-2

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