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Estrogen receptors genotypes and canine mammary neoplasia
BACKGROUND: Estrogens are essential for the development and proper function of several hormone-dependent organs. There are, however, several lines of evidence associating estrogens with mammary carcinogenesis. A marked individual genetic variability concerning estrogens biosynthesis, metabolism and...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6734279/ https://www.ncbi.nlm.nih.gov/pubmed/31506083 http://dx.doi.org/10.1186/s12917-019-2062-y |
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author | Canadas-Sousa, Ana Santos, Marta Leal, Bárbara Medeiros, Rui Dias-Pereira, Patrícia |
author_facet | Canadas-Sousa, Ana Santos, Marta Leal, Bárbara Medeiros, Rui Dias-Pereira, Patrícia |
author_sort | Canadas-Sousa, Ana |
collection | PubMed |
description | BACKGROUND: Estrogens are essential for the development and proper function of several hormone-dependent organs. There are, however, several lines of evidence associating estrogens with mammary carcinogenesis. A marked individual genetic variability concerning estrogens biosynthesis, metabolism and mechanism of action was recognized and associated with human breast cancer susceptibility, clinical features and progression. Although some genetic variations in canine ESR1 gene were reported, their influence in clinicopathological features and progression of canine mammary tumors has not been fully evaluated. This study aims to assess the influence of SNPs in ESR1 gene (rs397512133, rs397510462, rs851327560, rs397510612, rs852887655, rs852684753 and rs852398698) in canine mammary tumors characteristics and progression. A group of 155 non-neutered bitches with mammary tumors was included in the study. Follow-up information was assessed 24 months after surgery. RESULTS: Genetic profiles associated with a later onset of mammary tumors and less aggressive clinicopathological features, namely smaller tumor size (≤ 3 cm) with extensive tubular differentiation and low canine-adapted prognostic index (vet-NPI), were identified in this study. CONCLUSIONS: Our data suggest that the ESR1 genetic profile may help on the decision regarding the selection of individual tailored preventive measures against canine mammary tumors development, such as early neutering. |
format | Online Article Text |
id | pubmed-6734279 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-67342792019-09-12 Estrogen receptors genotypes and canine mammary neoplasia Canadas-Sousa, Ana Santos, Marta Leal, Bárbara Medeiros, Rui Dias-Pereira, Patrícia BMC Vet Res Research Article BACKGROUND: Estrogens are essential for the development and proper function of several hormone-dependent organs. There are, however, several lines of evidence associating estrogens with mammary carcinogenesis. A marked individual genetic variability concerning estrogens biosynthesis, metabolism and mechanism of action was recognized and associated with human breast cancer susceptibility, clinical features and progression. Although some genetic variations in canine ESR1 gene were reported, their influence in clinicopathological features and progression of canine mammary tumors has not been fully evaluated. This study aims to assess the influence of SNPs in ESR1 gene (rs397512133, rs397510462, rs851327560, rs397510612, rs852887655, rs852684753 and rs852398698) in canine mammary tumors characteristics and progression. A group of 155 non-neutered bitches with mammary tumors was included in the study. Follow-up information was assessed 24 months after surgery. RESULTS: Genetic profiles associated with a later onset of mammary tumors and less aggressive clinicopathological features, namely smaller tumor size (≤ 3 cm) with extensive tubular differentiation and low canine-adapted prognostic index (vet-NPI), were identified in this study. CONCLUSIONS: Our data suggest that the ESR1 genetic profile may help on the decision regarding the selection of individual tailored preventive measures against canine mammary tumors development, such as early neutering. BioMed Central 2019-09-10 /pmc/articles/PMC6734279/ /pubmed/31506083 http://dx.doi.org/10.1186/s12917-019-2062-y Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Canadas-Sousa, Ana Santos, Marta Leal, Bárbara Medeiros, Rui Dias-Pereira, Patrícia Estrogen receptors genotypes and canine mammary neoplasia |
title | Estrogen receptors genotypes and canine mammary neoplasia |
title_full | Estrogen receptors genotypes and canine mammary neoplasia |
title_fullStr | Estrogen receptors genotypes and canine mammary neoplasia |
title_full_unstemmed | Estrogen receptors genotypes and canine mammary neoplasia |
title_short | Estrogen receptors genotypes and canine mammary neoplasia |
title_sort | estrogen receptors genotypes and canine mammary neoplasia |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6734279/ https://www.ncbi.nlm.nih.gov/pubmed/31506083 http://dx.doi.org/10.1186/s12917-019-2062-y |
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