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Estrogen receptors genotypes and canine mammary neoplasia

BACKGROUND: Estrogens are essential for the development and proper function of several hormone-dependent organs. There are, however, several lines of evidence associating estrogens with mammary carcinogenesis. A marked individual genetic variability concerning estrogens biosynthesis, metabolism and...

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Autores principales: Canadas-Sousa, Ana, Santos, Marta, Leal, Bárbara, Medeiros, Rui, Dias-Pereira, Patrícia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6734279/
https://www.ncbi.nlm.nih.gov/pubmed/31506083
http://dx.doi.org/10.1186/s12917-019-2062-y
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author Canadas-Sousa, Ana
Santos, Marta
Leal, Bárbara
Medeiros, Rui
Dias-Pereira, Patrícia
author_facet Canadas-Sousa, Ana
Santos, Marta
Leal, Bárbara
Medeiros, Rui
Dias-Pereira, Patrícia
author_sort Canadas-Sousa, Ana
collection PubMed
description BACKGROUND: Estrogens are essential for the development and proper function of several hormone-dependent organs. There are, however, several lines of evidence associating estrogens with mammary carcinogenesis. A marked individual genetic variability concerning estrogens biosynthesis, metabolism and mechanism of action was recognized and associated with human breast cancer susceptibility, clinical features and progression. Although some genetic variations in canine ESR1 gene were reported, their influence in clinicopathological features and progression of canine mammary tumors has not been fully evaluated. This study aims to assess the influence of SNPs in ESR1 gene (rs397512133, rs397510462, rs851327560, rs397510612, rs852887655, rs852684753 and rs852398698) in canine mammary tumors characteristics and progression. A group of 155 non-neutered bitches with mammary tumors was included in the study. Follow-up information was assessed 24 months after surgery. RESULTS: Genetic profiles associated with a later onset of mammary tumors and less aggressive clinicopathological features, namely smaller tumor size (≤ 3 cm) with extensive tubular differentiation and low canine-adapted prognostic index (vet-NPI), were identified in this study. CONCLUSIONS: Our data suggest that the ESR1 genetic profile may help on the decision regarding the selection of individual tailored preventive measures against canine mammary tumors development, such as early neutering.
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spelling pubmed-67342792019-09-12 Estrogen receptors genotypes and canine mammary neoplasia Canadas-Sousa, Ana Santos, Marta Leal, Bárbara Medeiros, Rui Dias-Pereira, Patrícia BMC Vet Res Research Article BACKGROUND: Estrogens are essential for the development and proper function of several hormone-dependent organs. There are, however, several lines of evidence associating estrogens with mammary carcinogenesis. A marked individual genetic variability concerning estrogens biosynthesis, metabolism and mechanism of action was recognized and associated with human breast cancer susceptibility, clinical features and progression. Although some genetic variations in canine ESR1 gene were reported, their influence in clinicopathological features and progression of canine mammary tumors has not been fully evaluated. This study aims to assess the influence of SNPs in ESR1 gene (rs397512133, rs397510462, rs851327560, rs397510612, rs852887655, rs852684753 and rs852398698) in canine mammary tumors characteristics and progression. A group of 155 non-neutered bitches with mammary tumors was included in the study. Follow-up information was assessed 24 months after surgery. RESULTS: Genetic profiles associated with a later onset of mammary tumors and less aggressive clinicopathological features, namely smaller tumor size (≤ 3 cm) with extensive tubular differentiation and low canine-adapted prognostic index (vet-NPI), were identified in this study. CONCLUSIONS: Our data suggest that the ESR1 genetic profile may help on the decision regarding the selection of individual tailored preventive measures against canine mammary tumors development, such as early neutering. BioMed Central 2019-09-10 /pmc/articles/PMC6734279/ /pubmed/31506083 http://dx.doi.org/10.1186/s12917-019-2062-y Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Canadas-Sousa, Ana
Santos, Marta
Leal, Bárbara
Medeiros, Rui
Dias-Pereira, Patrícia
Estrogen receptors genotypes and canine mammary neoplasia
title Estrogen receptors genotypes and canine mammary neoplasia
title_full Estrogen receptors genotypes and canine mammary neoplasia
title_fullStr Estrogen receptors genotypes and canine mammary neoplasia
title_full_unstemmed Estrogen receptors genotypes and canine mammary neoplasia
title_short Estrogen receptors genotypes and canine mammary neoplasia
title_sort estrogen receptors genotypes and canine mammary neoplasia
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6734279/
https://www.ncbi.nlm.nih.gov/pubmed/31506083
http://dx.doi.org/10.1186/s12917-019-2062-y
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