Effects of monoclonal antagonist antibodies on calcitonin gene-related peptide receptor function and trafficking

BACKGROUND: Monoclonal antibodies against calcitonin gene-related peptide (CGRP) or its receptor are efficacious for the prevention of migraine headaches. The downstream molecular mechanisms following ligand-receptor blockade by which these antibodies prevent CGRP signaling through CGRP receptors ha...

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Detalles Bibliográficos
Autores principales: Manoukian, Raffi, Sun, Hong, Miller, Silke, Shi, Di, Chan, Brian, Xu, Cen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Milan 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6734291/
https://www.ncbi.nlm.nih.gov/pubmed/31039731
http://dx.doi.org/10.1186/s10194-019-0992-1

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