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Autonomic nervous system response to remote ischemic conditioning: heart rate variability assessment
BACKGROUND: Remote ischemic conditioning (RIC) is a procedure applied in a limb for triggering endogenous protective pathways in distant organs, namely brain or heart. The underlying mechanisms of RIC are still not fully understood, and it is hypothesized they are mediated either by humoral factors,...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6734354/ https://www.ncbi.nlm.nih.gov/pubmed/31500561 http://dx.doi.org/10.1186/s12872-019-1181-5 |
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author | Noronha Osório, Daniel Viana-Soares, Ricardo Marto, João Pedro Mendonça, Marcelo D. Silva, Hugo P. Quaresma, Cláudia Viana-Baptista, Miguel Gamboa, Hugo Vieira, Helena L. A. |
author_facet | Noronha Osório, Daniel Viana-Soares, Ricardo Marto, João Pedro Mendonça, Marcelo D. Silva, Hugo P. Quaresma, Cláudia Viana-Baptista, Miguel Gamboa, Hugo Vieira, Helena L. A. |
author_sort | Noronha Osório, Daniel |
collection | PubMed |
description | BACKGROUND: Remote ischemic conditioning (RIC) is a procedure applied in a limb for triggering endogenous protective pathways in distant organs, namely brain or heart. The underlying mechanisms of RIC are still not fully understood, and it is hypothesized they are mediated either by humoral factors, immune cells and/or the autonomic nervous system. Herein, heart rate variability (HRV) was used to evaluate the electrophysiological processes occurring in the heart during RIC and, in turn to assess the role of autonomic nervous system. METHODS: Healthy subjects were submitted to RIC protocol and electrocardiography (ECG) was used to evaluate HRV, by assessing the variability of time intervals between two consecutive heart beats. This is a pilot study based on the analysis of 18 ECG from healthy subjects submitted to RIC. HRV was characterized in three domains (time, frequency and non-linear features) that can be correlated with the autonomic nervous system function. RESULTS: RIC procedure increased significantly the non-linear parameter SD2, which is associated with long term HRV. This effect was observed in all subjects and in the senior (> 60 years-old) subset analysis. SD2 increase suggests an activation of both parasympathetic and sympathetic nervous system, namely via fast vagal response (parasympathetic) and the slow sympathetic response to the baroreceptors stimulation. CONCLUSIONS: RIC procedure modulates both parasympathetic and sympathetic autonomic nervous system. Furthermore, this modulation is more pronounced in the senior subset of subjects. Therefore, the autonomic nervous system regulation could be one of the mechanisms for RIC therapeutic effectiveness. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12872-019-1181-5) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-6734354 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-67343542019-09-12 Autonomic nervous system response to remote ischemic conditioning: heart rate variability assessment Noronha Osório, Daniel Viana-Soares, Ricardo Marto, João Pedro Mendonça, Marcelo D. Silva, Hugo P. Quaresma, Cláudia Viana-Baptista, Miguel Gamboa, Hugo Vieira, Helena L. A. BMC Cardiovasc Disord Research Article BACKGROUND: Remote ischemic conditioning (RIC) is a procedure applied in a limb for triggering endogenous protective pathways in distant organs, namely brain or heart. The underlying mechanisms of RIC are still not fully understood, and it is hypothesized they are mediated either by humoral factors, immune cells and/or the autonomic nervous system. Herein, heart rate variability (HRV) was used to evaluate the electrophysiological processes occurring in the heart during RIC and, in turn to assess the role of autonomic nervous system. METHODS: Healthy subjects were submitted to RIC protocol and electrocardiography (ECG) was used to evaluate HRV, by assessing the variability of time intervals between two consecutive heart beats. This is a pilot study based on the analysis of 18 ECG from healthy subjects submitted to RIC. HRV was characterized in three domains (time, frequency and non-linear features) that can be correlated with the autonomic nervous system function. RESULTS: RIC procedure increased significantly the non-linear parameter SD2, which is associated with long term HRV. This effect was observed in all subjects and in the senior (> 60 years-old) subset analysis. SD2 increase suggests an activation of both parasympathetic and sympathetic nervous system, namely via fast vagal response (parasympathetic) and the slow sympathetic response to the baroreceptors stimulation. CONCLUSIONS: RIC procedure modulates both parasympathetic and sympathetic autonomic nervous system. Furthermore, this modulation is more pronounced in the senior subset of subjects. Therefore, the autonomic nervous system regulation could be one of the mechanisms for RIC therapeutic effectiveness. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12872-019-1181-5) contains supplementary material, which is available to authorized users. BioMed Central 2019-09-09 /pmc/articles/PMC6734354/ /pubmed/31500561 http://dx.doi.org/10.1186/s12872-019-1181-5 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Noronha Osório, Daniel Viana-Soares, Ricardo Marto, João Pedro Mendonça, Marcelo D. Silva, Hugo P. Quaresma, Cláudia Viana-Baptista, Miguel Gamboa, Hugo Vieira, Helena L. A. Autonomic nervous system response to remote ischemic conditioning: heart rate variability assessment |
title | Autonomic nervous system response to remote ischemic conditioning: heart rate variability assessment |
title_full | Autonomic nervous system response to remote ischemic conditioning: heart rate variability assessment |
title_fullStr | Autonomic nervous system response to remote ischemic conditioning: heart rate variability assessment |
title_full_unstemmed | Autonomic nervous system response to remote ischemic conditioning: heart rate variability assessment |
title_short | Autonomic nervous system response to remote ischemic conditioning: heart rate variability assessment |
title_sort | autonomic nervous system response to remote ischemic conditioning: heart rate variability assessment |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6734354/ https://www.ncbi.nlm.nih.gov/pubmed/31500561 http://dx.doi.org/10.1186/s12872-019-1181-5 |
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