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Obesity and Polycystic Ovary Syndrome: Implications for Pathogenesis and Novel Management Strategies

Polycystic ovary syndrome (PCOS) is a common female condition typified by reproductive, hyperandrogenic, and metabolic features. Polycystic ovary syndrome is a genetic condition, exacerbated by obesity. There is a close link between obesity and PCOS based on epidemiological data, and more recently c...

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Autores principales: Barber, Thomas M, Hanson, Petra, Weickert, Martin O, Franks, Stephen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6734597/
https://www.ncbi.nlm.nih.gov/pubmed/31523137
http://dx.doi.org/10.1177/1179558119874042
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author Barber, Thomas M
Hanson, Petra
Weickert, Martin O
Franks, Stephen
author_facet Barber, Thomas M
Hanson, Petra
Weickert, Martin O
Franks, Stephen
author_sort Barber, Thomas M
collection PubMed
description Polycystic ovary syndrome (PCOS) is a common female condition typified by reproductive, hyperandrogenic, and metabolic features. Polycystic ovary syndrome is a genetic condition, exacerbated by obesity. There is a close link between obesity and PCOS based on epidemiological data, and more recently corroborated through genetic studies. There are many mechanisms mediating the effects of weight-gain and obesity on the development of PCOS. The metabolic effects of insulin resistance and steroidogenic and reproductive effects of hyperinsulinaemia are important mechanisms. Adipokine production by subcutaneous and visceral fat appears to play a part in metabolic function. However, given the complexity of PCOS pathogenesis, it is important also to consider possible effects of PCOS on further weight-gain, or at least on hampering attempts at weight-loss and maintenance through lifestyle changes. Possible mediators of these effects include changes in energy expenditure, mental ill health, or physical inactivity. In this brief review, we discuss the main mechanisms that underlie the association between obesity and PCOS, from divergent perspectives of weight-gain contributing to development of PCOS and vice versa. We also consider novel management options for women with obesity and PCOS.
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spelling pubmed-67345972019-09-13 Obesity and Polycystic Ovary Syndrome: Implications for Pathogenesis and Novel Management Strategies Barber, Thomas M Hanson, Petra Weickert, Martin O Franks, Stephen Clin Med Insights Reprod Health The Many Faces of PCOS Polycystic ovary syndrome (PCOS) is a common female condition typified by reproductive, hyperandrogenic, and metabolic features. Polycystic ovary syndrome is a genetic condition, exacerbated by obesity. There is a close link between obesity and PCOS based on epidemiological data, and more recently corroborated through genetic studies. There are many mechanisms mediating the effects of weight-gain and obesity on the development of PCOS. The metabolic effects of insulin resistance and steroidogenic and reproductive effects of hyperinsulinaemia are important mechanisms. Adipokine production by subcutaneous and visceral fat appears to play a part in metabolic function. However, given the complexity of PCOS pathogenesis, it is important also to consider possible effects of PCOS on further weight-gain, or at least on hampering attempts at weight-loss and maintenance through lifestyle changes. Possible mediators of these effects include changes in energy expenditure, mental ill health, or physical inactivity. In this brief review, we discuss the main mechanisms that underlie the association between obesity and PCOS, from divergent perspectives of weight-gain contributing to development of PCOS and vice versa. We also consider novel management options for women with obesity and PCOS. SAGE Publications 2019-09-09 /pmc/articles/PMC6734597/ /pubmed/31523137 http://dx.doi.org/10.1177/1179558119874042 Text en © The Author(s) 2019 http://www.creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle The Many Faces of PCOS
Barber, Thomas M
Hanson, Petra
Weickert, Martin O
Franks, Stephen
Obesity and Polycystic Ovary Syndrome: Implications for Pathogenesis and Novel Management Strategies
title Obesity and Polycystic Ovary Syndrome: Implications for Pathogenesis and Novel Management Strategies
title_full Obesity and Polycystic Ovary Syndrome: Implications for Pathogenesis and Novel Management Strategies
title_fullStr Obesity and Polycystic Ovary Syndrome: Implications for Pathogenesis and Novel Management Strategies
title_full_unstemmed Obesity and Polycystic Ovary Syndrome: Implications for Pathogenesis and Novel Management Strategies
title_short Obesity and Polycystic Ovary Syndrome: Implications for Pathogenesis and Novel Management Strategies
title_sort obesity and polycystic ovary syndrome: implications for pathogenesis and novel management strategies
topic The Many Faces of PCOS
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6734597/
https://www.ncbi.nlm.nih.gov/pubmed/31523137
http://dx.doi.org/10.1177/1179558119874042
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