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The matter of the reproductive microbiome

The preconceptional presence of microbiota in the female and male reproductive organs suggests that fertilization is taking place in a nonsterile environment and contributes to reproductive success. The concept of embryonic development in a sterile uterus has also been challenged with recent reports...

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Detalles Bibliográficos
Autores principales: Schoenmakers, Sam, Steegers-Theunissen, Regine, Faas, Marijke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6734629/
https://www.ncbi.nlm.nih.gov/pubmed/31523266
http://dx.doi.org/10.1177/1753495X18775899
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author Schoenmakers, Sam
Steegers-Theunissen, Regine
Faas, Marijke
author_facet Schoenmakers, Sam
Steegers-Theunissen, Regine
Faas, Marijke
author_sort Schoenmakers, Sam
collection PubMed
description The preconceptional presence of microbiota in the female and male reproductive organs suggests that fertilization is taking place in a nonsterile environment and contributes to reproductive success. The concept of embryonic development in a sterile uterus has also been challenged with recent reports of the existence of a microbiome of the placenta, amniotic fluid and the fetal gut in normal, uncomplicated pregnancies. The maternal origins of the microbiota colonising the fetus and its surroundings are unknown as are the mechanisms of maternal-to-fetal transfer. In this review, we aim to highlight the preconception male and female microbiome, the maternal vaginal and gut microbiome during pregnancy and the fetal microbiome, including their possible roles in reproduction, and maternal and neonatal pregnancy outcome.
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spelling pubmed-67346292020-09-01 The matter of the reproductive microbiome Schoenmakers, Sam Steegers-Theunissen, Regine Faas, Marijke Obstet Med Review Articles The preconceptional presence of microbiota in the female and male reproductive organs suggests that fertilization is taking place in a nonsterile environment and contributes to reproductive success. The concept of embryonic development in a sterile uterus has also been challenged with recent reports of the existence of a microbiome of the placenta, amniotic fluid and the fetal gut in normal, uncomplicated pregnancies. The maternal origins of the microbiota colonising the fetus and its surroundings are unknown as are the mechanisms of maternal-to-fetal transfer. In this review, we aim to highlight the preconception male and female microbiome, the maternal vaginal and gut microbiome during pregnancy and the fetal microbiome, including their possible roles in reproduction, and maternal and neonatal pregnancy outcome. SAGE Publications 2018-05-17 2019-09 /pmc/articles/PMC6734629/ /pubmed/31523266 http://dx.doi.org/10.1177/1753495X18775899 Text en © The Author(s) 2018 http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Review Articles
Schoenmakers, Sam
Steegers-Theunissen, Regine
Faas, Marijke
The matter of the reproductive microbiome
title The matter of the reproductive microbiome
title_full The matter of the reproductive microbiome
title_fullStr The matter of the reproductive microbiome
title_full_unstemmed The matter of the reproductive microbiome
title_short The matter of the reproductive microbiome
title_sort matter of the reproductive microbiome
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6734629/
https://www.ncbi.nlm.nih.gov/pubmed/31523266
http://dx.doi.org/10.1177/1753495X18775899
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