Cargando…
Metastatic components in colorectal cancer
Recent experiments have shown that cells with different genetic mutations can give rise to cancer transformation, both in vitro and in vivo, supported by the crosstalk between cancer cells and stroma. The stroma and the complex set of involved cells make up the tumor microenvironment that supports t...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6734673/ https://www.ncbi.nlm.nih.gov/pubmed/31523261 http://dx.doi.org/10.4103/jrms.JRMS_957_18 |
_version_ | 1783450193266475008 |
---|---|
author | Javarsiani, Marjan Hajimoradi Javanmard, Shagayegh Haghjooy Colonna, Francesca |
author_facet | Javarsiani, Marjan Hajimoradi Javanmard, Shagayegh Haghjooy Colonna, Francesca |
author_sort | Javarsiani, Marjan Hajimoradi |
collection | PubMed |
description | Recent experiments have shown that cells with different genetic mutations can give rise to cancer transformation, both in vitro and in vivo, supported by the crosstalk between cancer cells and stroma. The stroma and the complex set of involved cells make up the tumor microenvironment that supports the engraftment of metastatic cells. In fact, environmental factors support colorectal cancer arise by formation and maintenance of cancer stem cells (CSCs). In this review, we discuss interactions between CSCs and their microenvironment that can provide better therapeutic opportunities in the metastatic cancer. |
format | Online Article Text |
id | pubmed-6734673 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-67346732019-09-13 Metastatic components in colorectal cancer Javarsiani, Marjan Hajimoradi Javanmard, Shagayegh Haghjooy Colonna, Francesca J Res Med Sci Review Article Recent experiments have shown that cells with different genetic mutations can give rise to cancer transformation, both in vitro and in vivo, supported by the crosstalk between cancer cells and stroma. The stroma and the complex set of involved cells make up the tumor microenvironment that supports the engraftment of metastatic cells. In fact, environmental factors support colorectal cancer arise by formation and maintenance of cancer stem cells (CSCs). In this review, we discuss interactions between CSCs and their microenvironment that can provide better therapeutic opportunities in the metastatic cancer. Wolters Kluwer - Medknow 2019-08-28 /pmc/articles/PMC6734673/ /pubmed/31523261 http://dx.doi.org/10.4103/jrms.JRMS_957_18 Text en Copyright: © 2019 Journal of Research in Medical Sciences http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Review Article Javarsiani, Marjan Hajimoradi Javanmard, Shagayegh Haghjooy Colonna, Francesca Metastatic components in colorectal cancer |
title | Metastatic components in colorectal cancer |
title_full | Metastatic components in colorectal cancer |
title_fullStr | Metastatic components in colorectal cancer |
title_full_unstemmed | Metastatic components in colorectal cancer |
title_short | Metastatic components in colorectal cancer |
title_sort | metastatic components in colorectal cancer |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6734673/ https://www.ncbi.nlm.nih.gov/pubmed/31523261 http://dx.doi.org/10.4103/jrms.JRMS_957_18 |
work_keys_str_mv | AT javarsianimarjanhajimoradi metastaticcomponentsincolorectalcancer AT javanmardshagayeghhaghjooy metastaticcomponentsincolorectalcancer AT colonnafrancesca metastaticcomponentsincolorectalcancer |