Metastatic components in colorectal cancer

Recent experiments have shown that cells with different genetic mutations can give rise to cancer transformation, both in vitro and in vivo, supported by the crosstalk between cancer cells and stroma. The stroma and the complex set of involved cells make up the tumor microenvironment that supports t...

Descripción completa

Detalles Bibliográficos
Autores principales: Javarsiani, Marjan Hajimoradi, Javanmard, Shagayegh Haghjooy, Colonna, Francesca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2019
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6734673/
https://www.ncbi.nlm.nih.gov/pubmed/31523261
http://dx.doi.org/10.4103/jrms.JRMS_957_18
_version_ 1783450193266475008
author Javarsiani, Marjan Hajimoradi
Javanmard, Shagayegh Haghjooy
Colonna, Francesca
author_facet Javarsiani, Marjan Hajimoradi
Javanmard, Shagayegh Haghjooy
Colonna, Francesca
author_sort Javarsiani, Marjan Hajimoradi
collection PubMed
description Recent experiments have shown that cells with different genetic mutations can give rise to cancer transformation, both in vitro and in vivo, supported by the crosstalk between cancer cells and stroma. The stroma and the complex set of involved cells make up the tumor microenvironment that supports the engraftment of metastatic cells. In fact, environmental factors support colorectal cancer arise by formation and maintenance of cancer stem cells (CSCs). In this review, we discuss interactions between CSCs and their microenvironment that can provide better therapeutic opportunities in the metastatic cancer.
format Online
Article
Text
id pubmed-6734673
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Wolters Kluwer - Medknow
record_format MEDLINE/PubMed
spelling pubmed-67346732019-09-13 Metastatic components in colorectal cancer Javarsiani, Marjan Hajimoradi Javanmard, Shagayegh Haghjooy Colonna, Francesca J Res Med Sci Review Article Recent experiments have shown that cells with different genetic mutations can give rise to cancer transformation, both in vitro and in vivo, supported by the crosstalk between cancer cells and stroma. The stroma and the complex set of involved cells make up the tumor microenvironment that supports the engraftment of metastatic cells. In fact, environmental factors support colorectal cancer arise by formation and maintenance of cancer stem cells (CSCs). In this review, we discuss interactions between CSCs and their microenvironment that can provide better therapeutic opportunities in the metastatic cancer. Wolters Kluwer - Medknow 2019-08-28 /pmc/articles/PMC6734673/ /pubmed/31523261 http://dx.doi.org/10.4103/jrms.JRMS_957_18 Text en Copyright: © 2019 Journal of Research in Medical Sciences http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Review Article
Javarsiani, Marjan Hajimoradi
Javanmard, Shagayegh Haghjooy
Colonna, Francesca
Metastatic components in colorectal cancer
title Metastatic components in colorectal cancer
title_full Metastatic components in colorectal cancer
title_fullStr Metastatic components in colorectal cancer
title_full_unstemmed Metastatic components in colorectal cancer
title_short Metastatic components in colorectal cancer
title_sort metastatic components in colorectal cancer
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6734673/
https://www.ncbi.nlm.nih.gov/pubmed/31523261
http://dx.doi.org/10.4103/jrms.JRMS_957_18
work_keys_str_mv AT javarsianimarjanhajimoradi metastaticcomponentsincolorectalcancer
AT javanmardshagayeghhaghjooy metastaticcomponentsincolorectalcancer
AT colonnafrancesca metastaticcomponentsincolorectalcancer

Ejemplares similares