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Where there is sodium there may be sepsis
Hypernatremia affects up to 9% of critically ill patients upon hospital admission, especially in elderly patients with thirst impairment. However, hypernatremia is not entirely explained by fluid imbalance. Recent studies suggest that sodium is an important enhancer of the immune system, raising the...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6735289/ https://www.ncbi.nlm.nih.gov/pubmed/31528275 http://dx.doi.org/10.1080/20009666.2019.1634407 |
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author | De Freitas, Gerson Gudur, Anuragh Vela-Ortiz, Myriam Jodelka, Jacek Livert, David Krishnamurthy, Mahesh |
author_facet | De Freitas, Gerson Gudur, Anuragh Vela-Ortiz, Myriam Jodelka, Jacek Livert, David Krishnamurthy, Mahesh |
author_sort | De Freitas, Gerson |
collection | PubMed |
description | Hypernatremia affects up to 9% of critically ill patients upon hospital admission, especially in elderly patients with thirst impairment. However, hypernatremia is not entirely explained by fluid imbalance. Recent studies suggest that sodium is an important enhancer of the immune system, raising the question of whether inflammatory states such as sepsis may contribute to hypernatremia. Although sepsis patients with hypernatremia face a greater mortality rate, there is a lack of studies examining a potential association between hypernatremia and sepsis. Motivated by the frequent concurrence of hypernatremia and sepsis observed at an eastern Pennsylvanian community hospital, the current study was conducted to evaluate whether hypernatremia on admission may serve as a potential surrogate marker for sepsis. The medical records of 153 patients with hypernatremia on admission (serum sodium > 145mEq/L) were retrospectively analyzed. The mean age of patients was 81.1. Sepsis was observed in 77.1% of patients, of which 86.2% had dementia. This study demonstrated a positive correlation between hypernatremia on admission and the presence of sepsis. We suggest that the existence of hypernatremia should prompt clinicians to further investigate for sources of infection, especially in the elderly and patients with dementia. |
format | Online Article Text |
id | pubmed-6735289 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-67352892019-09-16 Where there is sodium there may be sepsis De Freitas, Gerson Gudur, Anuragh Vela-Ortiz, Myriam Jodelka, Jacek Livert, David Krishnamurthy, Mahesh J Community Hosp Intern Med Perspect Research Article Hypernatremia affects up to 9% of critically ill patients upon hospital admission, especially in elderly patients with thirst impairment. However, hypernatremia is not entirely explained by fluid imbalance. Recent studies suggest that sodium is an important enhancer of the immune system, raising the question of whether inflammatory states such as sepsis may contribute to hypernatremia. Although sepsis patients with hypernatremia face a greater mortality rate, there is a lack of studies examining a potential association between hypernatremia and sepsis. Motivated by the frequent concurrence of hypernatremia and sepsis observed at an eastern Pennsylvanian community hospital, the current study was conducted to evaluate whether hypernatremia on admission may serve as a potential surrogate marker for sepsis. The medical records of 153 patients with hypernatremia on admission (serum sodium > 145mEq/L) were retrospectively analyzed. The mean age of patients was 81.1. Sepsis was observed in 77.1% of patients, of which 86.2% had dementia. This study demonstrated a positive correlation between hypernatremia on admission and the presence of sepsis. We suggest that the existence of hypernatremia should prompt clinicians to further investigate for sources of infection, especially in the elderly and patients with dementia. Taylor & Francis 2019-09-05 /pmc/articles/PMC6735289/ /pubmed/31528275 http://dx.doi.org/10.1080/20009666.2019.1634407 Text en © 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group on behalf of Greater Baltimore Medical Center. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article De Freitas, Gerson Gudur, Anuragh Vela-Ortiz, Myriam Jodelka, Jacek Livert, David Krishnamurthy, Mahesh Where there is sodium there may be sepsis |
title | Where there is sodium there may be sepsis |
title_full | Where there is sodium there may be sepsis |
title_fullStr | Where there is sodium there may be sepsis |
title_full_unstemmed | Where there is sodium there may be sepsis |
title_short | Where there is sodium there may be sepsis |
title_sort | where there is sodium there may be sepsis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6735289/ https://www.ncbi.nlm.nih.gov/pubmed/31528275 http://dx.doi.org/10.1080/20009666.2019.1634407 |
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