Uncontrolled recurrent myasthenia gravis exacerbations secondary to chronic gabapentin use

Gabapentin is an anticonvulsant medication that reduces synaptic transmission by decreasing presynaptic voltage-gated Ca2+ and Na+ channels. It is approved to treat focal seizures but also used to treat post-herpetic and neuropathic pain. Although uncommon, there have been three reported cases of my...

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Autores principales: Chien, Jason L., Baez, Valentina, Mody, Harshad R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6735302/
https://www.ncbi.nlm.nih.gov/pubmed/31528296
http://dx.doi.org/10.1080/20009666.2019.1643220
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author Chien, Jason L.
Baez, Valentina
Mody, Harshad R.
author_facet Chien, Jason L.
Baez, Valentina
Mody, Harshad R.
author_sort Chien, Jason L.
collection PubMed
description Gabapentin is an anticonvulsant medication that reduces synaptic transmission by decreasing presynaptic voltage-gated Ca2+ and Na+ channels. It is approved to treat focal seizures but also used to treat post-herpetic and neuropathic pain. Although uncommon, there have been three reported cases of myasthenia gravis exacerbation associated with gabapentin in the literature. We present a patient with uncontrolled recurrent myasthenia gravis exacerbations secondary to chronic gabapentin use and provide a review for the three published cases.
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spelling pubmed-67353022019-09-16 Uncontrolled recurrent myasthenia gravis exacerbations secondary to chronic gabapentin use Chien, Jason L. Baez, Valentina Mody, Harshad R. J Community Hosp Intern Med Perspect Case Report Gabapentin is an anticonvulsant medication that reduces synaptic transmission by decreasing presynaptic voltage-gated Ca2+ and Na+ channels. It is approved to treat focal seizures but also used to treat post-herpetic and neuropathic pain. Although uncommon, there have been three reported cases of myasthenia gravis exacerbation associated with gabapentin in the literature. We present a patient with uncontrolled recurrent myasthenia gravis exacerbations secondary to chronic gabapentin use and provide a review for the three published cases. Taylor & Francis 2019-09-05 /pmc/articles/PMC6735302/ /pubmed/31528296 http://dx.doi.org/10.1080/20009666.2019.1643220 Text en © 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group on behalf of Greater Baltimore Medical Center. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Chien, Jason L.
Baez, Valentina
Mody, Harshad R.
Uncontrolled recurrent myasthenia gravis exacerbations secondary to chronic gabapentin use
title Uncontrolled recurrent myasthenia gravis exacerbations secondary to chronic gabapentin use
title_full Uncontrolled recurrent myasthenia gravis exacerbations secondary to chronic gabapentin use
title_fullStr Uncontrolled recurrent myasthenia gravis exacerbations secondary to chronic gabapentin use
title_full_unstemmed Uncontrolled recurrent myasthenia gravis exacerbations secondary to chronic gabapentin use
title_short Uncontrolled recurrent myasthenia gravis exacerbations secondary to chronic gabapentin use
title_sort uncontrolled recurrent myasthenia gravis exacerbations secondary to chronic gabapentin use
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6735302/
https://www.ncbi.nlm.nih.gov/pubmed/31528296
http://dx.doi.org/10.1080/20009666.2019.1643220
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