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A rare case of metastatic small cell neuroendocrine carcinoma of the lung presenting as isolated thrombocytopenia

Small cell neuroendocrine carcinoma (SNEC) is a high grade and poorly differentiated neuroendocrine tumor which typically presents as a primary pulmonary neoplasm near the bronchial region. Due to the aggressive nature of the tumor, there are many ways it can initially present, mostly involving the...

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Autores principales: DeMarinis, Adreana, Malik, Fahad, Matin, Tommy, Rahmany, Zalmi, Putnam, Taylor, Nfonoyim, Jay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6735311/
https://www.ncbi.nlm.nih.gov/pubmed/31528281
http://dx.doi.org/10.1080/20009666.2019.1644916
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author DeMarinis, Adreana
Malik, Fahad
Matin, Tommy
Rahmany, Zalmi
Putnam, Taylor
Nfonoyim, Jay
author_facet DeMarinis, Adreana
Malik, Fahad
Matin, Tommy
Rahmany, Zalmi
Putnam, Taylor
Nfonoyim, Jay
author_sort DeMarinis, Adreana
collection PubMed
description Small cell neuroendocrine carcinoma (SNEC) is a high grade and poorly differentiated neuroendocrine tumor which typically presents as a primary pulmonary neoplasm near the bronchial region. Due to the aggressive nature of the tumor, there are many ways it can initially present, mostly involving the lungs. We present a case of a 68-year-old male patient who initially presented with new-onset of severe thrombocytopenia with superimposed pneumonia. It was late in the progression of the disease that histopathology from the bone marrow confirmed SNEC, which presented only after it metastasized to the bone marrow by way of a rare paraneoplastic syndrome. Furthermore, the bone marrow biopsy revealed atypical markers not commonly seen in SNEC. Since this was such an atypical presentation of SNEC, management was limited to stabilization of the patient. The patient expired two weeks later.
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spelling pubmed-67353112019-09-16 A rare case of metastatic small cell neuroendocrine carcinoma of the lung presenting as isolated thrombocytopenia DeMarinis, Adreana Malik, Fahad Matin, Tommy Rahmany, Zalmi Putnam, Taylor Nfonoyim, Jay J Community Hosp Intern Med Perspect Case Report Small cell neuroendocrine carcinoma (SNEC) is a high grade and poorly differentiated neuroendocrine tumor which typically presents as a primary pulmonary neoplasm near the bronchial region. Due to the aggressive nature of the tumor, there are many ways it can initially present, mostly involving the lungs. We present a case of a 68-year-old male patient who initially presented with new-onset of severe thrombocytopenia with superimposed pneumonia. It was late in the progression of the disease that histopathology from the bone marrow confirmed SNEC, which presented only after it metastasized to the bone marrow by way of a rare paraneoplastic syndrome. Furthermore, the bone marrow biopsy revealed atypical markers not commonly seen in SNEC. Since this was such an atypical presentation of SNEC, management was limited to stabilization of the patient. The patient expired two weeks later. Taylor & Francis 2019-09-05 /pmc/articles/PMC6735311/ /pubmed/31528281 http://dx.doi.org/10.1080/20009666.2019.1644916 Text en © 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group on behalf of Greater Baltimore Medical Center. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
DeMarinis, Adreana
Malik, Fahad
Matin, Tommy
Rahmany, Zalmi
Putnam, Taylor
Nfonoyim, Jay
A rare case of metastatic small cell neuroendocrine carcinoma of the lung presenting as isolated thrombocytopenia
title A rare case of metastatic small cell neuroendocrine carcinoma of the lung presenting as isolated thrombocytopenia
title_full A rare case of metastatic small cell neuroendocrine carcinoma of the lung presenting as isolated thrombocytopenia
title_fullStr A rare case of metastatic small cell neuroendocrine carcinoma of the lung presenting as isolated thrombocytopenia
title_full_unstemmed A rare case of metastatic small cell neuroendocrine carcinoma of the lung presenting as isolated thrombocytopenia
title_short A rare case of metastatic small cell neuroendocrine carcinoma of the lung presenting as isolated thrombocytopenia
title_sort rare case of metastatic small cell neuroendocrine carcinoma of the lung presenting as isolated thrombocytopenia
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6735311/
https://www.ncbi.nlm.nih.gov/pubmed/31528281
http://dx.doi.org/10.1080/20009666.2019.1644916
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