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ETV2/ER71 Transcription Factor as a Therapeutic Vehicle for Cardiovascular Disease
Cardiovascular diseases have long been the leading cause of mortality and morbidity in the United States as well as worldwide. Despite numerous efforts over the past few decades, the number of the patients with cardiovascular disease still remains high, thereby necessitating the development of novel...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ivyspring International Publisher
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6735401/ https://www.ncbi.nlm.nih.gov/pubmed/31534512 http://dx.doi.org/10.7150/thno.35300 |
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author | Lee, Dong Hun Kim, Tae Min Kim, Joo Kyung Park, Changwon |
author_facet | Lee, Dong Hun Kim, Tae Min Kim, Joo Kyung Park, Changwon |
author_sort | Lee, Dong Hun |
collection | PubMed |
description | Cardiovascular diseases have long been the leading cause of mortality and morbidity in the United States as well as worldwide. Despite numerous efforts over the past few decades, the number of the patients with cardiovascular disease still remains high, thereby necessitating the development of novel therapeutic strategies equipped with a better understanding of the biology of the cardiovascular system. Recently, the ETS transcription factor, ETV2 (also known as ER71), has been recognized as a master regulator of the development of the cardiovascular system and plays an important role in pathophysiological angiogenesis and the endothelial cell reprogramming. Here, we discuss the detailed mechanisms underlying ETV2/ER71-regulated cardiovascular lineage development. In addition, recent reports on the novel functions of ETV2/ER71 in neovascularization and direct cell reprogramming are discussed with a focus on its therapeutic potential for cardiovascular diseases. |
format | Online Article Text |
id | pubmed-6735401 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Ivyspring International Publisher |
record_format | MEDLINE/PubMed |
spelling | pubmed-67354012019-09-18 ETV2/ER71 Transcription Factor as a Therapeutic Vehicle for Cardiovascular Disease Lee, Dong Hun Kim, Tae Min Kim, Joo Kyung Park, Changwon Theranostics Review Cardiovascular diseases have long been the leading cause of mortality and morbidity in the United States as well as worldwide. Despite numerous efforts over the past few decades, the number of the patients with cardiovascular disease still remains high, thereby necessitating the development of novel therapeutic strategies equipped with a better understanding of the biology of the cardiovascular system. Recently, the ETS transcription factor, ETV2 (also known as ER71), has been recognized as a master regulator of the development of the cardiovascular system and plays an important role in pathophysiological angiogenesis and the endothelial cell reprogramming. Here, we discuss the detailed mechanisms underlying ETV2/ER71-regulated cardiovascular lineage development. In addition, recent reports on the novel functions of ETV2/ER71 in neovascularization and direct cell reprogramming are discussed with a focus on its therapeutic potential for cardiovascular diseases. Ivyspring International Publisher 2019-08-09 /pmc/articles/PMC6735401/ /pubmed/31534512 http://dx.doi.org/10.7150/thno.35300 Text en © The author(s) This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions. |
spellingShingle | Review Lee, Dong Hun Kim, Tae Min Kim, Joo Kyung Park, Changwon ETV2/ER71 Transcription Factor as a Therapeutic Vehicle for Cardiovascular Disease |
title | ETV2/ER71 Transcription Factor as a Therapeutic Vehicle for Cardiovascular Disease |
title_full | ETV2/ER71 Transcription Factor as a Therapeutic Vehicle for Cardiovascular Disease |
title_fullStr | ETV2/ER71 Transcription Factor as a Therapeutic Vehicle for Cardiovascular Disease |
title_full_unstemmed | ETV2/ER71 Transcription Factor as a Therapeutic Vehicle for Cardiovascular Disease |
title_short | ETV2/ER71 Transcription Factor as a Therapeutic Vehicle for Cardiovascular Disease |
title_sort | etv2/er71 transcription factor as a therapeutic vehicle for cardiovascular disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6735401/ https://www.ncbi.nlm.nih.gov/pubmed/31534512 http://dx.doi.org/10.7150/thno.35300 |
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