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CRISPR-based Activation of Endogenous Neurotrophic Genes in Adipose Stem Cell Sheets to Stimulate Peripheral Nerve Regeneration

Background: Peripheral nerve regeneration requires coordinated functions of neurotrophic factors and neuronal cells. CRISPR activation (CRISPRa) is a powerful tool that exploits inactive Cas9 (dCas9), single guide RNA (sgRNA) and transcription activator for gene activation, but has yet to be harness...

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Detalles Bibliográficos
Autores principales:	Hsu, Mu-Nung, Liao, Han-Tsung, Truong, Vu Anh, Huang, Kai-Lun, Yu, Fu-Jen, Chen, Hwei-Hsien, Nguyen, Thi Kieu Nuong, Makarevich, Pavel, Parfyonova, Yelena, Hu, Yu-Chen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2019
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6735509/ https://www.ncbi.nlm.nih.gov/pubmed/31534539 http://dx.doi.org/10.7150/thno.36790

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